多靶点、多途径治疗病毒感染性疾病是目前抗病毒药物研发的新趋势。前期研究发现治疗流行性感冒的临床验方“岗藿抗感汤”可激活宿主的RIG-I/IFN-I固有免疫通路，网络药理学预测和动物实验结果显示其还可以调控HIF-1信号通路以阻断炎性介质瀑布反应诱发的ALI/ARDS，发现并部分阐明了岗梅和广藿香的抗流感病毒分子机制，提示其具有多途径治疗流行性感冒的特点。本研究借鉴中医动态适应性平衡的思想，从病毒感染早期激活RIG-I信号通路诱导I型干扰素的产生和后期通过下游HIF-1途径回馈抑制炎症因子的释放，实现“促炎-抗炎”平衡的分子机制，探讨岗藿抗感汤对炎症反应激活和回馈的分子机制，同时进一步阐明方药中各成分、部位抑制病毒复制的阶段和分子机制。揭示中医药多成分、多靶点、多途径、协同治疗流行性感冒的优势和特点，为岗藿抗感汤的进一步开发和临床应用提供科学支撑。

Multi-target, multi-channel treatment of viral infectious diseases is a new trend in the development of antiviral drugs. Previous studies have found that the clinical prescription for the treatment of influenza "Ganghuokanggan Decoction" can activate the host's RIG-I / IFN-I innate immune pathway, and network pharmacology predictions and experiment in vivo result showed that it can also regulate HIF-1 signaling pathway to prevent ALI/ARDS by blocking inflammatory mediators, and have found and partially elucidated the molecular mechanism of anti-influenza virus of Gangmei and Patchouli, suggesting that it has multiple ways to treat influenza. This study draws on the idea of ​​TCM dynamic adaptability balance to explore the molecular mechanism of Ganghuokanggan Decoction on inflammatory response activation and feedback by activating the RIG-I signaling pathway from the early stage of viral infection to induce the production of typeⅠ interferon and regulating the downstream HIF-1 feedback pathway to inhibit the release of inflammatory factors, which realize the molecular mechanism of the "pro-inflammatory-anti-inflammatory" balance, and further elucidate the stage and molecular mechanism of inhibition of viral replication in various components and sites. It will reveal the treatment of epidemic influenza of traditional Chinese medicine with the advantages and characteristics of multi-component, multi-target and multi-channel, and provide scientific support for the further development and clinical application of Ganghuokanggan Decoction.