2型糖尿病发病率逐年升高，糖尿病心肌病也呈现出逐年上升的态势，此病早期诊断困难，往往确诊时已伴发心力衰竭，致残率和致死率居高不下。而关于糖尿病心肌病的病理机制目前还存在争议，主流学说认为胰岛素抵抗介导的心肌能量代谢通路在糖尿病心肌病演进中起到决定性的作用，且心肌早期脂肪变性是糖尿病心肌病的最初病理学改变。因此，本研究拟采用MRS（包括氢谱与磷谱）、化学交换饱和转移（CEST）和T1mapping等多种磁共振成像技术，联合胰岛素抵抗检测技术、体外心脏灌注、病理学检查，并采用回归分析方法，在活体2型糖尿病大鼠模型上对糖尿病心肌病心肌脂肪变、胰岛素抵抗介导的心肌能量代谢障碍进行定量研究，寻求糖尿病心肌病早期诊断的特异性影像学标记及其界定值，从而为临床上早期诊断及评估糖尿病心肌病提供重要的参考价值。

The incidence of Type 2 diabetes mellitus is increasing with years, and diabetic cardiomyopathy also showed an upward trend year by year. The early diagnosis of the disease is difficult, and often diagnosed with heart failure, resulting in high disability and mortality. The pathological mechanism of diabetic cardiomyopathy is still controversial. Basically, the dominant view agreed that insulin resistance-mediated myocardial energy metabolism pathway plays a critical role in the evolution of diabetic cardiomyopathy, and the fatty degeneration in cardiomyocytes is the earliest pathological features of diabetic cardiomyopathy. Therefore, this study will use MRS (including hydrogen spectrum and phosphorus spectrum), chemical exchange saturation transfer (CEST), myocardial T1-mapping and other magnetic resonance imaging technologies, combining with insulin resistance detection technique, cardiac perfusion in vitro and pathological examination, in order to evaluate myocardial steatosis and insulin resistance-induced early myocardial energy metabolic disorder quantitatively on rat model of T2DM in vivo. Finally, specific imaging markers for early diagnosis of diabetic cardiomyopathy and their reference ranges will be found, which could provide important value for clinical early diagnosis and evaluation of diabetic cardiomyopathy.