给水系统中致免疫毒性的病原相关分子模式污染释放分布和风险控制

微生物死亡解体释放的多种自身结构组分为病原相关分子模式（简称PAMPs），属于免疫刺激剂，具有病原感染功能，刺激机体免疫系统诱发炎症，导致多种慢性疾病和自身免疫性疾病。PAMPs属医学免疫学的重要前沿，目前国内外饮用水领域尚未见PAMPs提出。饮用水微生物死亡释放出PAMPs，通过呼吸暴露和肠胃暴露刺激免疫系统导致健康危害，尚未见报道。基于前期基础，拟将免疫学的PAMPs概念创新性的引入饮用水领域；建立饮用水PAMPs污染检测和致炎风险评估方法；研究城市供水系统PAMPs污染释放分布和致炎风险；阐明给水生物处理工艺PAMPs致炎风险，评估生物处理的安全性；搭建模拟给水管网装置，解析管网生物膜多相体系PAMPs污染释放的关键影响因子和响应规律；搭建模拟水处理消毒装置，研究水处理消毒技术对水中PAMPs物质释放影响和控制；旨在为有效阻断给水系统PAMPs的炎症危害提供依据和支持，保障健康饮水。

Many kinds of structural components releasing from the body of microbes, have the characteristics of pathogen-associated molecular patterns (PAMPs) with functions of pathogen infection. PAMPs stimulate the innate immune system, attribute to strong immune responses and inflammation effects, and closely related to a variety of chronic diseases and autoimmune diseases. PAMPs are the key field of medical immunology research. However, PAMPs in drinking water had not been reported and should be aroused more attention. Microbial death in drinking water releases PAMPs, which stimulate the immune system through respiratory and gastrointestinal exposure and are at risk of immune-toxicity. Based on our previous research, the PAMPs in medical immunology research will be introduced to the drinking water filed. Detection method for single contamination of PAMPs and assessment method of inflammation risk for combined contamination of PAMPs in drinking water will be established. The release, distribution and inflammatory risk of PAMPs contamination in urban water supply system will be investigated. PAMPs releasing from biological activated carbon unit was investigated to assess the safety of biological treatment processes for water supply. And distribution characteristics, key factors and response of pipeline biofilm in the multiphase system of PAMPs will also be analyzed using by the simulating water supply pipe network. The release and control efficiencies of PAMPs by the water treatment and disinfection technique were investigated by simulating water treatment experiments. Our research aims at controlling of PAMPs in drinking water, which will fully identify and effectively block the inflammatory risk of PAMPs in water supply system.