基于铁羰基化合物的光诱导一氧化碳释放剂研究

一氧化碳（CO）有剧毒，但它是一个内源性的气体分子，有重要生理和药用作用，如在器官移植中有减轻排异反应和提高移植成活率的作用。CO释放分子（CORMs）是发挥CO药用作用的重要化合物（主要是金属羰基化合物）。本研究项目将围绕基于铁羰基化合物的CORMs就化合物合成与表征、CO释放及释放机理、CO释放性能与化合物结构之间的构效关系开展研究。以单茂铁和二铁羰基化合物为研究对象，重点研究内容为：1、探讨二铁羰基化合物具备光诱导释放CO性能的必要条件，建立其CO释放性能与化合物的LUMO能级（还原电位）之间的相关性，探索调控其CO释放性能的有效途径；2、研究红光或近红外光诱导促进亲核取代反应释放CO的动力学和CO释放机理。本项目的研究将有助于缩小我国在这方面与国际水平的差距、丰富低能量光诱导促进化学反应的研究、找到新型的CO释放方法，为研发新型的具有自主知识产权的光诱导CORMs新药奠定基础。

Carbon monoxide (CO) is poisonous but it is endogenous gaseous molecule with important physiological functions. It plays a role in the reduction of rejection and promotion of survival in transplantation. CO-releasing molecules (CORMs) are a category of important molecules (mainly organometallic compounds) for implementing the medical application of CO. In this project, synthesis and characterisation of iron-carbonyl complexes, their CO-releasing and mechanisms, structure-function relation between the CO-releasing property and structures will be investigated. By using iron-cyclopentodiene-carbonyl and diirom carbonyl complexes, the research will be focused on following two aspects: 1. Exploring the fundamental requirement for a CORM to be photo-active, establishing the correlation between photo-induced CO-releasing and its LUMO energy (reduction potential) and exploring effective approaches to tune its CO-releasing activity; 2. Investigating the kinetics of CO-releasing induced by red or near infrared lights and further promoted by nucleophilic substitution reaction and CO-releasing mechanism. To unfold the research of this project will narrow the research gap between China and other countries on CORMs, enrich the chemistry of reaction induced and promoted by the lights of low energy, figure out novel approaches of CO-releasing and lay down a foundation for developing novel photo-induced CORMs drugs of our own intellectual property rights.