生物钟是机体用以协调组织与器官的生理节律以及行为节律，使之与自然界的昼夜节律相和谐的一个完整调控系统。当环境改变的时候，生物钟引发从细胞到机体的应答，从而确保机体能在环境改变中适应性生存，因此生物钟成为了维持外界环境变化与体内生理和行为适应的重要系统。在本项目的申请中，我们假设：两个主要的光线与食物的环境因素牵引能够重塑生物钟的鲁棒性也能破坏生物钟，因此寻找合适的两者时空调节将是干预生物钟的关键。我们以小鼠作为最初的模式动物，提出了三个主要研究内容：（1）SCN神经多肽与神经元对输出的生理行为影响；（2）研究SCN神经元的投射部位与主要牵引要素：光、食物的合成输出作用；（3）衰老等退行性病理状况下（1）与（2）的改变规律，探究牵引的分子机制，绘制食物和光线牵引过程的脑功能连接图。最终，我们期望建立干预手段，发展人的电子行为产品，期望会对人类个体化生物钟的干预提供新的理论和干预方法。

The temporal coordination of internal biological processes, both among these processes and with external environmental cycles, is crucial to the health and survival of diverse organisms. The environmental signals trigger the clock system responses that ensure the organism can survive in the internal and external environment and maintenance of physiological and behavioral adaptation. In this proposal, we intend to test the hypothesis that light and food entrainment can reprogram the circadian clock and disorganize the clock system. To achieve these goals, we propose three main research areas of studies: (1) The effects of neuropeptides and SCN neurons on the output system; (2) Investigate intra-SCN connectivity and the neural pathways by food and light entrainment; (3) Discuss their alteration during circadian defects or aging processes. Eventually, we aim at developing a system for human electrical behavior apparatus based on the theory by providing appropriately-timed exposure to light and food that can trigger the reset of timing such as sleep and wake to the desired times, and subsequently, enhance overall sleep quality and daytime alertness. This also will be significant for combating circadian-related other diseases, aging and for improving human life quality.