出生前WiFi和1800MHz射频暴露对大鼠海马MFGE8的作用效应研究

随着网络时代的发展，移动电话和WiFi信号已经成为组成微环境射频辐射的主要因素，公众反复暴露于一个叠加的复合射频电磁场中，其可能带来的健康效应越来越受到关注。MFG-E8有促进吞噬并抑制炎症的作用，被认为是脑梗死，阿尔茨海默症，蛛网膜下腔出血等疾病的内源性保护因子。小胶质细胞在防御有害因素所致神经损伤和修复等方面发挥重要作用。MFG-E8与小胶质细胞单独和相互之间的作用对神经功能正常发挥有重要意义。文献报道和我们的研究都显示，微波能改变小胶质细胞活化和MFG-E8表达状态，但具体作用机制不明确。本次研究我们拟在前期发现的基础上探讨出生前暴露于手机和WiFi叠加射频场对不同时期子代大鼠海马脑区内源性MFG-E8的表达、小胶质细胞活化及其与MFG-E8的相互作用进行研究，以便更全面认识手机和WiFi叠加射频场暴露对大鼠海马脑区的影响，为电磁波生物学效应和相关卫生政策的研究和制定提供实验室证据。

With the development of the Internet age, mobile phone and WiFi signal has become the main factors of radio frequency exposure of microwave environment, The health effects produced by two kinds of superposition of the electromagnetic radiation is gradually attention abroad, but domestic research reports are rarely at present.Some studies suggested MFG - E8 promote phagocytosis and inhibit inflammation, cerebral infarction, alzheimer's disease, subarachnoid hemorrhage disease such as endogenous protective factor. Microglia play an important role in defense nerve damage caused by harmful factors and tissue repair, etc. MFG - E8 and Microglia individually or jointly in the brain is important for normal nerve function. The literature and our study shows that the microwave altered microglia activation and MFG - E8 expression in never systerm. But the mechanism of action and interaction between them is not clear. In this research, we will elucidate and discuss the expression of MFGE8, microglia activation and its interaction mechanism, after prenatal exposure to cell phone and WiFi RF field for offspring rats in different hippocampal regions.Through evaluation of the health effects produced by two kinds of superposition of the electromagnetic radiation, new scientific basis would been found and established for risk assessment and standards setting of radio frequency electromagnetic radiation.