溃疡性结肠炎（UC）是指一种原因不明的非特异肠道炎症性疾，迄今病因和发病机制尚不明确。外泌体（Exosomes）是免疫细胞间的功能性载体，其中RAB27是目前被发现存在于肠道黏膜外泌体中参与Treg细胞免疫反应的miRNA。近年的研究表明Th17/Treg平衡是维持肠道免疫稳态的重要因素，其失衡是导致UC的主要原因之一。以外泌体中RAB27为载体，研究RAB27与GSK-3β信号通路的关系，可揭示miRNA递送信息的途径，有利于了解外泌体与GSK-3β信号通路调控Th17/Treg平衡在UC中的作用。同时，我们用清热解毒中药肠安方进行干预，探索中药对肠道外泌体与GSK-3β信号通路和Th17/Treg平衡的作用和影响，进一步揭示UC的发病机制和探索中药治疗UC的作用靶点。

Ulcerative colitis (UC) is a kind of refractory intestinal inflammatory disease, the main pathogenesis of which is intestinal mucosal immune response. Exosomes, a small membrane vesicles that secreted into the extracellular environment, are emerging as another important intercellular messenger in immune responses. RAB27 is a small GTPases involved in exosome secretion, involved in Treg cells in the immune response of microRNAs. It is one of the main causes of UC: the balance of Th17 / Treg. Studying of RAB27 as the carrier in the body with GSK-3 beta signaling pathways, the miRNA way of delivering information can be revealed, it will be to understand the relationship of GSK- 3 beta signaling pathways and Th17 / Treg balance in UC. At the same time, we use im Chinese medicine CAS to intervene, in order to exploring the effects of traditional Chinese medicine(TCM) on GSK- 3 beta signaling pathways and the role of Th17 / Treg balance and influence, further reveal the pathogenesis of UC and explore the traditional TCM targets for the treatment of UC.