Behcet病是我国常见的致盲性葡萄膜炎类型，被认为是典型的自身免疫性疾病。CD4+T（Th17/Treg）细胞介导的免疫反应是发病的重要机制，而Th17/Treg细胞失衡可上溯至树突状细胞（DC）活化及功能异常。我们预实验发现miRNA-132基因拷贝数变异（CNV）与Behcet病显著相关，活动期Behcet病患者miRNA-132表达有显著异常，提示miRNA-132可能参与调控Behcet病。本项目以Behcet病为研究对象，通过差异性表达miRNA-132来探讨其对DC分化、成熟功能以及Th17和Treg细胞分化的影响；通过靶基因确定来探讨其对上述影响的分子机制；通过干预动物模型来评价其对炎症发生、发展及转归的影响以及对葡萄膜炎的防治作用和潜在的应用价值。旨在阐明miRNA-132在Behcet病中是如何影响免疫细胞功能及其分子机制，为Behcet病的防治研究提供新的靶点和策略。

Behcet's disease (BD) is the most important uveitis entities in China. It's recognized to be the typical autoimmune diseases. The disequilibrium of Th17/Treg cell and the disfunction of DC were found to play important roles in the pathogenisis of these diseases. Our recent study have found a significant association of the CNV of miRNA-132 with BD and a significant difference of the expression of miRNA-132 in active BD patients, suggesting an involvement of this miRNA in this disease. This project is aimed to identify miRNA-132 in BD. The differential expession of miRNA-132 will be identified on the activation and function of DC and the differentiation of Th17/Treg cell. The target gene of miRNA-132 will be determined. The experimental autoimmune uveitis model will be used to evaluate the effect of miRNA-132 on the development and the outcome of BD. This research will illuminate the role of miRNA-132 in the pathogenesis of disease and provide us with a new insight into the prevention and treatment of BD.