温度和pH双振荡对原始汤RNA自复制的驱动效应

综合考虑生物起源的原始汤热循环理论、地球化学时空梯度理论和“RNA世界” 学说，设计具有温度和pH双无机化学振荡体系(过氧化氢-硫代硫酸盐-亚硫酸盐体系等)来模拟生命起源热液喷口附近的原始汤介质，同时原始汤振荡介质中具有非叠加镜像对映体的某些无机物（如过氧化氢） 与有机分子手性选择反应，造成涨落的非线性放大而产生手性破缺（即同手性化），本项目研究温度和pH双振荡驱动下的RNA分子复制动力学和活性过氧化氢驱动的分子手性破缺机制来理解地球生物起源规律同时探讨人造生命和其他星球生命的可能性,并且通过无机振荡动力学、RNA复制和输运三者相耦合形成的DNA传播波复杂结构来推测生命分子迁移带来生命起源的空间分布规律； 其次生物分子自催化复制和有机分子同手型化的影响因素和控制方法可潜在应用于生物制剂和手性药物的生产。

From integratedly considering three theories for the origins of life, i.e., thermal cycling of the primordial soup, the geochemical spatiotemporal gradient and "the RNA world", inorganic oscillations in both temperature and pH（Hydrogen peroxide - thiosulfate - thiosulfate system, et al. ） will be designed to mimic the media of the primordial soup near hydrothermal vents for the emergence of life. Meanwhile, some inorganic molecules, such as hydrogen peroxide in the media of oscillatory primordial soup, exist as pairs of non-superimposable mirror images, or enantiomers, which could interact anantiospecifically with some organic molecules, leading to chiral symmetry breaking, i. e., homochirality. This project will focus on dynamics of RNA replication and reactive hydrogen peroxide-induced chiral symmetry breaking, which are driven by oscillations in both temperature and pH, to understand the origins of life in earth and to investigate the possibilities of artificial life and life in other planets. Spatial distribution patterns for the emergence of life, resulting from migration of life molecules, could be also inferred from the complex structure of RNA propagation waves which could form through coupling between inorganic oscillatory kinetics, RNA self-replication and transportation. Additionally, the influence factors and control methods for RNA autocatalytic replication and homochirality of organic molecules could be applied potentially to the production of biological agents and chiral drugs.