猫豆是广西特色药用资源和经济作物，是提取左旋多巴的原料药材。长期以来，人们普遍认为猫豆中的猫豆毒苷是猫豆中毒引起昏迷的成分。然而，至今猫豆毒苷的化学结构国内外均未见报道。这导致猫豆食物中毒的临床治疗存在一定的推测性。猫豆胍是本课题组首次从猫豆中分离获得的新成分。其中枢抑制作用表明该物质极可能是猫豆中毒引起昏迷的成分。本项目是国家自然科学基金项目(30760309)的连续深入研究。拟通过神经电生理研究；体内分布及代谢产物研究；GABA受体结合活性实验；微透析结合HPLC法测定动物脑内Ach、DA、NA、5-HT、GABA、Gly、Glu、Asp和相关代谢产物DOPAC及5-HIAA含量，从而阐明猫豆胍的体内分布情况及其中枢抑制作用机理。为解释猫豆食物中毒的原因及猫豆食物中毒的临床治疗提供科学依据。项目研究具有鲜明的地方特色和创新性。研究成果可为猫豆的研究打开新的空间。

Stizotobium cochinchinensis is a characteristic medicinal resource and industrial crop in Guangxi, which can be used as raw medicinal material to extract levodopa. For a long time, it is generally believe that the component which leads to coma in the seed of Stizotobium cochinchinensis is a poisonous glycoside. However, to date, the chemical structure of this glycoside has never been reported, leading to a speculative treatment of the food poisoning of the seed. Mucunaguanide is a new component that we extracted from the seed of Stizotobium cochinchinensis, with central inhibition effect, which indicates it is the most possible component resulting in coma. This project is a continuous in-depth study of the National Natural Science Foundation Project (30760309). It aims to reveal the vivo distribution and central inhibition mechanism of mucunaguanide by nerve electrophysiological studies, in vivo distribution and metabolite researches, GABA receptor binding activity experiments, microdialysis and HPLC content determination of Ach, DA, NA,5-HT, GABA , Gly, Glu, Asp, and related metabolites DOPAC and 5-HIAA in animal brains. Base on these results, we reveal the true cause of food poisoning of the seed of Stizotobium cochinchinensis and provide scientific data for treatment of the food poisoning of the seed. This project, with distinctive local characteristics and innovation, will open a new research field for Stizotobium cochinchinensis.