为改变现有靶向药物载体材料类型单一、性能欠佳等现状，该项目拟借助环形磁场辅助手段制备磁性载药纳米材料，并将其应用于动物体靶向药物控制释放。项目的创新之处在于，在合成单分散磁性Fe3O4纳米颗粒，对其进行表面功能化修饰、提升其吸附稳定性和生物相容性的基础上，在环形磁场辅助作用下进行高效药物装载，并用于动物体靶向药物控释应用。采用环形磁场辅助合成法的优势在于：（一）药物分子可与功能化磁性纳米载体在范德华力、氢键和大分子缠绕作用下结合；（二）在环形磁场辅助作用下，药物分子被封装在定向排列的磁性纳米颗粒形成的微腔中，通过载体粒子与药物反复碰撞而形成稳定的载药纳米棒；（三）该棒状结构在交变磁场震荡作用下会解体而释放药物，解体后的单分散纳米颗粒更易被代谢排出，从而可避免载体材料在动物体内滞留而导致的负作用。因此，该载药纳米棒材料可以作为一种理想的磁靶向药物载体，用于肿瘤和癌症治疗等靶向药物传输领域。

To change the single type and poor performance of the existing magnetic targeting drug carrier, the project intends to prepare a kind of drug-loaded nanomaterial with the assistant of toroidal magnetic field. The material has a potential prospect in the field of bio-targeted drug delivery area. The innovation of the project is the induction of magnetic field to synthesis magnetic Fe3O4 nanoparticles, which will be surface functionally modified to promote itsstability and biocompatibility. Then a type of drug-loaded nanocomposites will be formed effectively with the assistant of toroidal magnetic field. The advantages of using the toroidal magnetic field is that firstly, drug molecules can be combined with functional magnetic carrier by winding action of macromolecules, Van der Waals forces and hydrogen bonding; secondly, the drug molecule is wrapped in microcavities formed by the ordered magnetic nanoparticles, which will be further collided and linked with the drug molecule, and finally form a rod-like drug-loaded nanocomposites; and what’s more, the rod-like structure would be re-disintegrated into nanoparticles under the action of an alternating magnetic field and release drug rapidly. The nanomaterial carrier is liable to be discharged by metabolism after disintegration, there by avoiding the negative effects caused by the retention of the loaded materials in vivo. Thus, the drug-loaded rod-like material can be used as an ideal magnetic targeting drug carrier for targeting tumor treatment and related fields.