经自然腔道内镜手术（NOTES）被视为更加微创、拥有巨大发展潜力的第三代微创外科技术。但单内镜操作方式，成为限制其发展的瓶颈问题。本研究拟在前期研究基础上，研发腹腔内胶囊式智能监视系统（IPCIMS），并应用该系统探索双（软式）内镜手术技术，通过胆囊切除术及输卵管结扎术的单/双内镜技术对照动物实验研究，证明该系统及双镜手术技术的可行性。建立一种全新的NOTES双内镜手术模式，为NOTES技术的进一步拓展创造条件。预期目标：1.研发出有自主知识产权的腹腔内智能监视系统，以实现超微创腹腔内监视技术。2.解决软镜难以进行双（多）镜联合治疗操作的瓶颈性问题。实现双镜联合的关键性技术突破。3. 申请国家及国际专利，发表高水平SCI论文，为NOTES技术进一步推广应用、使我国在NOTES领域占据国际领先地位奠定坚实的基础。

Natural Orifice Transluminal Endoscopic Surgery (NOTES) is considered to be the third-generation minimally invasive technique with even more minimal invasiveness and great potential for further development. However, the single-endoscope operation mode has become the bottleneck restricting its further development. This study aims to develop a new type of Intraperitoneal Capsule Intelligent Monitoring System (IPCIMS) on the basis of the prior research work, and to make the use of this system to explore the procedural techniques of double flexible endoscopes and to prove the feasibility of this system and the techniques of double-endoscope approaches by controlled animal experiments of cholecystectomy and tubal ligation in comparison between the techniques of single and double-endoscope modes. Establish an entirely new double-endoscope mode for NOTES and create conditions for the further development of NOTES technology. Expected objectives: 1. To develop an intraperitoneal intelligent monitoring system with independent intellectual property rights to realize ultra-minimally invasive intraperitoneal monitoring. 2. To solve the bottleneck problems of the collaborative manipulation of double-endoscope or multiple-endoscope modalities and make a critical break-though in this important arena. 3. To apply for international and national patents and publish high quality papers in SCI listed journals, to lay a solid foundation for the popularity of NOTES technology in clinical practices and for making our country in the leading position in the field of NOTES.