长期高血压导致血管重塑，微循环在其中最先受损，出现微血管稀疏。治疗高血压对逆转血管重构的研究已成为血管生物学研究的热点之一。肝阳上亢型高血压在原发性高血压中占有很大的比例。天麻钩藤饮是平肝潜阳治疗肝阳上亢型高血压的有效方剂。PI3K/Akt通路是介导细胞存活的一条经典通路，GSK-3β在细胞的生长、分化、突变和凋亡等活动中具有重要的调控作用。而研究显示原发性高血压与血管平滑肌的增殖加速与凋亡抑制失衡有关。天麻钩藤饮对于改善高血压微循环及其作用机制尚不明确。根据前期研究建立假说，从天麻钩藤饮调节PI3K/Akt信号通路及Bcl-2/Bax蛋白，抑制血管平滑肌细胞凋亡，改善高血压时血管平滑肌增殖与凋亡失衡的状态，减少血管应力改变，从而发挥降压作用，并通过对SHR大鼠的微血管、病理、蛋白及信号通路的研究来揭示验证假说。揭示平肝潜阳中药治疗肝阳上亢型高血压的机理并为进一步研究提供基础。

Long-term hypertension and vascular remodeling, in which microcirculation is the first to suffer，and which cause microvascular sparse. Treatment of hypertension on thereversal of vascular remodeling has become one of the hotspots in vascular biology. Liver yang hyperactivity hypertension accounting for a significant proportion in essential hypertension.The Tianmagouteng drink can treat liver yang hyperactivity hypertension by calming liver yang. The PI3K/Akt pathway is a classic-mediated cell survivalpathway, GSK-3β plays an important role in the regulation of cell growth, differentiation, mutation, and apoptosis activities. Studies have shown that essential hypertension is related to imblance of vascular smooth muscle proliferation, acceleration and inhibition of apoptosis. The mechanism of tianmagouteng drink improving hypertension microcirculation is not clear yet. Therefore,we assume that Tianmagouteng drink can regulate the PI3K/Akt signaling pathway, regulate the Bcl-2/Bax protein, inhibition the apoptosis of vascular smooth muscle cells, improve the status of hypertensive vascular smooth muscle cell proliferation and apoptosis imbalance, reducing the the blood vessels'changes by stress. So we reveal the test hypotheses through the research on capillaries, pathology, protein and signaling pathway of SHR rats . That we can reveal the mechanism of Chinese medicine treat of liver yang hypertension by calming liver yang and provide a basis for further research.