急性心肌梗死（AMI）是冠心病的一种严重发病类型，其发病危急，病死率极高，是急诊危重症的常见疾病之一。早期诊断，及时挽救濒死的心肌，是治疗AMI成功的关键。单核苷酸多态性（SNPs）系新一代的分子遗传标记，已经为临床提供了大量的致病易感基因位点。目前，被证实与AMI密切相关的易感基因并不多，而且AMI易感基因SNPs与其临床相关的研究还欠深入，故本研究在前期“基因与血脂、冠心病相关研究”的基础上拟通过比较确诊为急性心肌梗塞的广西汉族患者和与其同期相匹配的正常汉族人群各900例的6个AMI易感基因共10个SNPs位点基因频率分布的差异，分析它们是否与广西汉族人群急性心肌梗死的易感性、早期诊断以及疗效存在相关性，为临床筛选高危AMI人群、早期诊断AMI以及评估AMI的疗效提供帮助，进而为汉族人群AMI发病的分子遗传学提供理论基础和实验依据。

Acute myocardial infarction (AMI) is a severe type of coronary heart disease, which is one of the common diseases in emergency with the critical incidence and high mortality rate. Early diagnosis and timely rescue of dying myocardium is the key to successful treatment of AMI. Single nucleotide polymorphism (SNP) is the new generation of member genetic marker, and provided a large number of pathogenic susceptible genes for clinic. At present, the susceptibility gene of AMI that has been confirmed was not much, and the research between AMI susceptibility gene SNP and the clinical manifestations of AMI is superficial. Therefore, in this study, on the early foundation of the research between gene and serum lipids and coronary heart disease, the distribution difference of these ten SNPs will be compared between 900 AMI examples and 900 normal cases in Guangxi Han Nationality. This study will provide a theoretical basis and experimental basis of AMI molecular genetics in Han Nationality by analyzing the relevance between the two SNPs and susceptibility, the early diagnosis as well as the curative effect of AMI in Guangxi Han Nationality.