麦角生物碱是一类典型的3，4桥环组成的吲哚生物碱，目前已有多种天麦角碱用于神经退行性疾病的治疗。由于其特殊的结构以及优良的药理活性，引起了合成化学家的广泛关注。目前，随着过渡金属催化反应的发展，许多新的策略应用到该类生物碱的合成研究中，如Heck反应、 烯丙基反应和C-H键官能团化等。我们希望利用过渡金属催化的C4-H官能团反应与分子内脱羧偶联反应，实现该类生物碱的仿生高效合成。其中lysergic acid仿生合成步骤包括色氨酸底物C4-H烯基化反应，分子内脱羧与烯基偶联关环构建C环；在此基础上，发展分子内不对称脱羧烯丙基化反应，实现该类天然产物的不对称合成。另外agroclavine生物碱的合成关键为色氨酸底物C4-H炔基化反应，分子内脱羧与炔基偶联关环构建C环。开展本课题不仅可以为这类天然产物提供另一类高效的合成方法，而且能进行这类天然产物的多样性合成以及后续的药物化学研究。

Ergot alkaloids are typical indole alkaloids with 3,4-fused ring, and natural or semi-synthetic ones were approved for treatment or relief of neurodegenerative diseases. Due to their unique structures and good biological activities, both the biosynthetic and total syntheses of these natural products were widely studied. Especially, the development of transitional metal catalyzed reaction provided new synthetic strategies for the total syntheses, for example, Heck reaction、allylic reaction and C-H activation. In this project, we proposed the biomimetic strategy using the C-H activation and intramolecular decarboxylative reaction. The key steps of synthesis of lysergic acid include indole C4-H olefination and intramolecular decarboxylative Giese reaction，a chiral route by asymmetric decarboxylative allylic reaction will also be investigated; similarly, indole C4-H alkynylation followed by intramolecular decarboxyative coupling with alkyne provided the key precursor of agroclavine. The aim of this project is not only provide another efficient synthetic route of ergot alkaloids with biomimetric way, but also will prepare lots of ergot alkaloids for the further medical chemistry studies.