柔性透明贵金属微纳米阵列SERS衬底的构筑及对农残分子原位痕量检测的应用探索

针对农残分子快速、准确、原位痕量检测的难题，本项目提出基于表面增强拉曼散射（SERS）的技术，旨在构筑高质量柔性透明的贵金属微纳米结构阵列作为SERS衬底，开展基于SERS效应的农残分子的原位痕量检测的应用探索，主要内容包括：柔性透明贵金属微纳米结构阵列SERS衬底的批量化制造及结构参数的优化；揭示阵列结构参数与SERS活性、稳定性、信号均一性之间的关联性；实现阵列的等离激元共振（LSPR）在近红外区域的按需调控；明晰激光光源参数与SERS信号之间的联系；模拟计算阵列表面的电磁场分布；确立典型农残分子的浓度与SERS信号强度之间满足的函数关系，以及SERS谱图的指认与拉曼峰位的归属，为实用化和器件化奠定基础。显然，这项工作的开展，不仅具有学术价值，而且具有重要的实用前景。

Aim at the rapid, accurate and in-situ trace detection of pesticide residues, the technology based on Surface Enhanced Raman Scattering (SERS) is proposed in this project, and the purpose of this study is to construct a high quality flexible and transparent array of noble metal nanostructures as SERS substrate, and application of in-situ trace detection of pesticide residues was explored based on SERS effect, the main contents include: Mass production and optimization of structural parameters of flexible and transparent noble metal micro-nanostructure array SERS substrate; Reveal the relation between structured parameters of array and SERS activity, stability and signal homogeneity; Modulation on demand of the array's plasmon resonance (LSPR) in the near infrared region; Understand the relationship between laser source parameters and SERS signals; Simulation and calculation of localized electromagnetic field distribution on array surface; Establishment of the functional relationship between the concentration of typical pesticide residues and the signal strength of SERS, and identification of SERS spectra and the assignment of Raman peaks, which lay a foundation for the practical application and device application. Obviously, the development of this work has not only academic value, but also important practical prospect.