金属有机骨架(Metal-Organic Frameworks，简称MOF)荧光传感器检测金属离子是近几年比较热门的研究领域。但是此类MOF的种类较少，能够检测离子的类别有限，灵敏度及选择性有待提高，检测机理需要深入研究。本项目以离子检测的螯合作用机理为导向，首次合成含有巯基、羟基的共轭多吡啶类有机配体，将其与柔性的多齿羧酸配体和金属离子自组装，构筑具有螯合效应的MOF荧光传感器。利用MOF空腔内裸露的不饱和配位点（氧、氮和硫原子）与被检测的金属离子间的螯合作用实现对金属离子的检测。加入调制剂调控MOF的形貌，研究形貌及粒度对离子检测的影响。通过对检测机理的分析，指导配体及MOF的设计合成。本项目最终不仅能拓展MOF荧光传感器检测离子的种类范围，还将大幅度提升灵敏度，使基于MOF荧光传感器的离子检测技术能够在生物体内微量金属离子检测、饮用水质检测等方面具有实际应用价值。

The detection of trace metal ions by MOF (Metal-Organic Frameworks) fluorescent sensor is a popular research topic in recent years. But the varieties of MOFs need to be increased, the ranges of detected ions need be expanded, the sensitivity and selectivity need to be improved, and the detection mechanism need to be further studied. Based on the chelation mechanism of ion detection, we use new conjugated pyridines, flexible carboxylic acid ligands and metal ions to build MOF fluorescent sensors with chelate effect in this project. It is noteworthy that the detection of trace metal ions was carried out by the chelation interactions between metal ions and the unsaturated coordination sites (oxygen, nitrogen and sulfur) in the cavity. Moreover, the morphology of MOF was regulated by modulator, and the influence of the morphology and particle size was investigated. Finally, the synthesis of conjugated pyridines and MOF was guided by analyzing the detection mechanism. As a result, this project can not only expand the types of the MOF fluorescent sensors for detecting metal ions, but also greatly enhance the sensitivity. In addition, the MOF fluorescent sensors have high development and used value in detecting the trace metal ions in living organisms and drinking water.