MIL-53骨架亲/疏水性质和孔结构调控及其对果糖脱水制备HMF的色谱分离研究

5-羟甲基糠醛（HMF）是生物质能源转化为化学品和燃料过程中的重要平台化合物之一。提高HMF产率和实现其从果糖脱水反应体系中的高效分离是生物质应用的技术难点。针对上述问题，本项目提出采用色谱分离技术将HMF从果糖脱水体系中高效分离。根据HMF和副产物之间亲/疏水性质和分子几何构型的特点，选择金属有机骨架材料MIL-53作为吸附剂，从分子水平对其骨架亲/疏水性质和孔结构进行精准调控，优化吸附剂和待分离组分之间关键参数的匹配性，创制一种高效的HMF吸附分离材料。通过吸附热力学、动力学的研究以及分子光谱表征技术揭示吸附本质和吸附剂-吸附质之间的作用机制，结合连续流动固定床吸附器中建立的技术参数，强化色谱分离工艺，获得高纯度HMF化合物。本项目的开展将为果糖脱水反应-分离的过程强化提供技术支撑，同时进一步推动生物质平台化合物生产分离新技术的创新。

5-Hydroxymethyl furfural (HMF) is one of paramount platform chemicals for converting biomass to chemicals and fuels. At present, the key challenge in application of biomass is to enhance HMF yield and separate it efficiently from fructose dehydration process. In this project, the chromatographic separation technology is proposed to complete the aforementioned target. On the basis of typical characteristic in hydrophilicity/hydrophobicity and geometrical configuration of HMF and other by-products, metal-organic framework MIL-53 is employed as adsorbent. Moreover, the accurate tailoring in hydrophilicity/hydrophobicity and pore structure is conducted from molecular-lever to optimize key parameters in compatibility of adsorbent and other separation compositions. The resulting an effective material toward HMF adsorptive separation is developed. The adsorption nature and interaction mechanism of adsorbent-adsorbate are revealed by the systematic studies in adsorption thermodynamics, kinetics, and spectroscopic techniques. Furthermore, the technology in chromatographic separation process is intensified through relating the technical parameters obtained from continuous-flow fixed-bed equipment. The resulting HMF compound with high purity can be obtained. The knowledge gained from this project will provide a technical support for the process intensification of dehydration reaction and separation. Meanwhile, it would drive the technological innovation in production and separation of platform chemicals.