新型四唑基大环二聚体的合成及其性能研究

本项目基于四唑化合物具有的生物活性及含能特性，结合人工设计大环化合物在医药科学和材料科学研究中的最新进展，设计了三类具有C2对称性的新型四唑基大环化合物，拟通过环二聚反应的策略实现它们的简洁、高效合成。并拟根据这些大环化合物在生物活性测试和材料含能性能研究中的结果对母体化合物进行结构修饰，从而建立四唑基大环化合物的构效关系规律。

Tetrazole-containing compounds have many applications in the area of biological science and energetic materials science. Macrocyclic compounds are a family of important compounds for the research on medicinal chemistry and supramolecular chemistry. This proposal describes the design and synthesis of C2-symmetric tetrazole-containing macrocycles for the strudy on bioactivity assay and energetic property test. The high efficent synthesis of tetrazole-containing macrocycles is proposed to be based on cyclodimerization strategy. In addition, the macrocycles can be modified according to the result from bioactivity assays and energetic property tests, and thus lead to their structure-activity relationship.