全亲水性共聚物自组装系统具有良好的刺激响应性、结构可逆性以及丰富的自组装形态等优点，已成为大分子自组装领域的研究热点。然而，可生物降解吸收的全亲水性共聚物的研究很少，全降解全亲水性脂肪族聚酯基共聚物的研究尚为空白。本项目聚焦全降解全亲水性聚己内酯基共聚物研究，以4-氨基甲酸苄基酯-ε-己内酯为基本单体，通过与羧基官能团化己内酯单体共聚制备双亲水性聚（4-氨基-ε-己内酯）-b-聚（6-羧基-ε-己内酯）嵌段共聚物；通过NCA方法与氨基酸共聚，制备三类（接枝、嵌段、嵌段/接枝）全亲水性聚己内酯/多肽共聚物。重点研究不同侧基官能团对大分子自组装驱动力的影响、不同共聚物结构类形对自组装导向作用的差异，通过调节共聚物结构以及外部环境条件来调控其刺激响应的多重胶束化行为。项目将首次制备一类新型的全生物降解的全亲水性聚己内酯基共聚物，拓展双亲水性共聚物的研究领域，在生物医用领域有潜在的应用前景。

Double hydrophilic copolymers (DHCs) attract increasing interest due to the stimuli-responses, structure changes and the abundant shlf-assenmbly forms. However, the stduies on the biodegradable DHCs are still very limited and hardly any reports of the biodegradable double hydrophilic aliphatic polyester could be found up to now. The proposed project focuses on the study of the biodegradable double hydrophilic polycaprolactone based copolymers. First, water soluble poly(4-amino-ε-caprolactone)-b-poly(6-methylcarboxyl-ε- caprolactone) block copolymers will be synthesized via ring-opening polymerization of newly developed monomers, γ-(carbamic acid benzyl ester)-4-caprolactone and, 6- (benzyloxycarbonylmethyl)-ε-caprolactone using Sn(Oct)2 as catalyst; Double hydrophilic polycaprolactone / poly(α-amino acid) copolymers with block, graft, and block/graft structure will be synthesized via NCA using poly(4-amino-ε- caprolactone) as macroinitiator. Second, the driving force for the self assembly of the synthesized DHCs will be studied on the aspects of the polymeric structure (block, graft, and block/graft) and the functional groups of the DHCs. The schizophrenic micellization of DHCs will be adjusted by changing the polymeric structure and the external stimulus. The novel biodegradable double hydrophilic polycaprolactone based copolymers that have significant potential application in biomedical field are expected to be successfully synthesized with the fund of the proposed project.