重症肌无力(MG)是累及神经肌肉接头的自身免疫神经疾病，其发病不仅涉及免疫系统本身，还与HPA轴和免疫系统病理上相互影响密切相关，故治疗应针对HPA轴-免疫系进行综合干预。本课题在前期研究基础上，以HPA轴-免疫系为研究靶点，以补脾强力复方为干预因素，摘除肾上腺致HPA轴损伤，常规复制EAMG大鼠模型，观察各组大鼠胸腺等免疫组织COR受体基因与COR受体蛋白表达情况、组织病理改变，及血中免疫球蛋白、AchR-Ab及细胞因子水平，客观揭示HPA轴损伤对EAMG大鼠免疫系统的影响； 检测EAMG大鼠HPA轴细胞因子及其受体表达情况，HPA轴病理改变，血中 ACTH、COR水平，下丘脑CRH水平，观察EAMG大鼠免疫系统异常对HPA轴的影响；同时观察补脾强力复方的干预作用。 通过研究力图阐明MG的发生发展与HPA轴-免疫系统病理上的相互影响紧密联系，并进一步揭示补脾强力复方治疗MG的现代机制。

Myasthenia gravis (MG) is the involvement of the autoimmune neuromuscular joint nerve disease, its pathogenesis is not only involved in the immune system itself, also influence each other pathology and HPA axis and immune system are closely related, so the treatment should be aimed at the HPA axis - the immune system a comprehensive intervention. This topic on the basis of previous research, the HPA axis - the immune system as the research target, with the strength compound BuPi qiangli Chinese herbal mediicine in intervention factors, removal of the adrenal HPA axis damage, regular copy EAMG rats models, observed between groups rats thymus COR receptor genes and immune groups such as COR receptor protein expression, tissue pathological changes, and immunoglobulin content in the blood, AchR - Ab and cytokine levels, objectively reveal the HPA axis damage effect of the immune system of EAMG rats; Detection of EAMG rats cytokines and their receptors expression of HPA axis, HPA axis pathological changes, the blood level of ACTH, COR, the hypothalamus CRH levels, observation of EAMG rats with abnormal immune system effect on the HPA axis; At the same time observation of compound BuPi qiangli Chinese herbai medicine intervention effect. Through research to clarify the occurrence and development of MG and HPA axis - the immune system pathologically influence each other closely, and further to reveal the modern mechanism of compound BuPi qiangli Chinese herbal medicine treatment of MG.