磨蚀产生的金属离子/磨屑是人工关节安全使用的主要瓶颈。关节股颈/头、股柄/骨水泥界面处于缝隙腐蚀的敏感范围，并会随着患者运动发生微动磨损，界面的缝隙宽度会周期性变化，诱发不稳定缝隙腐蚀。缝隙内部具有低pH值、低氧和高Cl离子浓度等特点，蛋白质的带电性会发生反转，结构极易变化。宏观滑动磨蚀已有完整体系，但微动磨损-缝隙腐蚀的耦合效应主要作用于表面钝化膜，磨蚀交互影响要比宏观滑动更加明显，不能简单套用宏观磨蚀的机理。申请人在多年研究磨蚀的基础上，利用电化学、CSAFM等方法，将开展微动磨损-缝隙腐蚀-蛋白质交互作用的研究，通过对微动磨蚀与钝化膜半导体特性的相互影响规律，建立微动磨损能量损失与缝隙腐蚀反应之间的模型，获得动态变化的H和Cl对微动模式（粘着、部分滑动）的影响规律；通过对蛋白质在不稳定缝隙中吸附/脱附动态变化的研究，解释非稳态微动磨蚀与蛋白质的相互作用机制，优化人工关节表面的设计。

Metallic ions and debris may potentially affect the long term health and safety issues for patients with artificial joint replacements. However, the origins of metallic ions and debris are not clear. In previous work, the applicant noticed that beside the bearing surfaces between the acetabular head and cup, severe corrosion also occurs at the head neck and the stem surface. The head neck and the stem surface are thought to be very stable. However, during the movement of patients, fretting can occur at these two interfaces. In addition, the crevice at these two interfaces various with the movement of patients. It is no longer a stable crevice. As a result, low pH, low concentration of oxygen and high Cl ions content, the charge that proteins carry can change. In this application, we want to understand the adsorption and desorption properties of proteins and explain the effect of crevice corrosion to proteins. By using electrochemical methods, the effect of local low surface potential induced by fretting will be studies. A relationship between the energy dispersion and corrosion reactions will be established. Ultimately, the synergistic effect between unstable crevice corrosion and fretting can be understood.