眼眶结构特殊、功能重要，一侧毗邻副鼻窦空腔，局部血供差，缺乏成骨细胞，菲薄骨壁一旦损伤易造成患者视功能障碍和颅面畸形，需要应用材料进行修复。然而，临床现有修复材料不可降解，且易造成感染、排异等严重并发症。我们前期研究证明，骨髓基质干细胞（BMSCs）复合多孔支架材料可修复眼眶骨缺损、促进骨再生。但材料植入后降解速率与新骨形成不匹配，成骨效率低；且材料直接与副鼻窦空腔相通，局部微环境差，感染率居高不下。现有研究表明，人抗菌肽β-defensin2具有广谱抗菌、促进细胞增殖和分化、调节免疫、促进伤口愈合等多种功能。本项目针对眶骨再生效率低和植入材料并发感染的问题，提出应用β-defensin2修饰功能化可降解材料PSeD-M，修复犬眶壁标准骨缺损，评价其应用于眶骨修复和再生的安全性和有效性，探讨其促进眶骨再生的机制，有望为临床应用功能化材料实现自体骨再生提供新产品和新思路。

The orbit has a vital function and a special structure. It’s adjacent to the paranasal sinus cavity, of poor local blood supply and lacking in osteoblasts. Injuries of the orbital walls can cause visual dysfunction and craniofacial deformities, which need to be repaired by biomaterials. However, existing clinical materials are non-biodegradable, and can cause complications of infection, rejection, cyst formation, etc. Our previous studies demonstrated that porous scaffolds combined with bone mesenchymal stem cells (BMSCs) could promote bone regeneration. But the rates of material degradation and new bone formation do not match, and materials are directly exposed to paranasal sinus cavity, thus the osteogenesis efficacy is low while the infection rate is high. Studies showed that human antimicrobial peptideβ-defensin2 had a broad antimicrobial spectrum, and had functions of promoting cell proliferation and differentiation, regulating immune activity, and promoting wound healing. This project uses the functional biomaterial PSeD-M modified by β-defensin2 to repair dog orbital wall defect, evaluating the safety and effectiveness of its application in bone repair and regeneration and exploring its mechanism of promoting bone regeneration. The study is promising for clinical application of functional materials to achieve autologous bone regeneration with new products and new ideas.