有机无机杂化水凝胶的设计构筑及其纤维成形机理研究

具有高力学性能、功能传递与放大特性的各向异性水凝胶及其纤维材料是组织工程、生物医药领域急需而一直难以突破的材料。本项目拟以“微观单元设计-介观结构组装-宏观材料构筑”为研究思路，以具有光/电/磁等本征功能和特殊表面结构的多维度无机纳米材料(NPs)为活性交联点，以可聚合的齐聚物为有机单体，自下而上地设计构筑尺度、维度及功能可控的有机/无机杂化水凝胶(H-Gels)；并进一步建立动态聚合纺丝新方法，一步连续制备具有三维网络结构的有机/无机杂化水凝胶纤维(GFs)。系统研究反应单体在NPs表面的聚合及键接方式，实现NPs功能在H-Gels中的传递与放大；在线跟踪H-Gels制备与GFs成形过程，揭示H-Gels、GFs凝聚态结构在复杂外场下演变规律，阐明其微/介观结构与宏观响应性能的构效关系，为制备结构功能一体化新一代H-Gels、GFs提供新原理、新方法，并实现其在肿瘤诊断治疗中的应用。

Anisotropic organic/inorganic hybrid hydrogels (H-Gels) and the gel fiber materials (GFs) that exhibit surprising high mechanical strength and particular functionalities (e.g. magnetic, temperature, pH, etc.) transfer characteristics, allows for the utilization in diverse fields especially tissue engineering and bio-medicine. However, the application of existing hydrogels suffers from their inherent limitation. Here we develop a novel “bottom-up” platform based on the whole chain mode strategy that from nano-building blocks design to micro-structures assembly to macro-materials construction. The new hydrogels are achieved by using functional (such as light, electricity, magnetic) inorganic nanoparticles (NPs) as active cross-linking agent with diverse dimensions and special surface structures, for the construction of organic/inorganic hydrogels and fibers with controllable structure and functions. Furthermore, the dynamic-crosslinking-spinning will be introduced to realize one-step fabrication of novel GFs. In this project, we will systematically study the polymerization process of monomers on NPs surfaces and their interfacial interactions on molecular level, to realize the functionalities transfer and even amplification from NPs themselves to macroscale bulk hydrogels; in-situ online monitor the forming process of H-Gels and GFs, to reveal the revolution process of their condensed structures under complex external field; explore the relationship between nano/microstructure and responsiveness in bulk hydrogels, to provide new mechanisms and techniques for the construction of new generation of H-gels and GFs with integrated structure and function, achieving their application in fields of tumor diagnosis and treatment.