飞行员在特殊作业环境下面对高脑力负荷工作容易产生疲劳状态，导致工作效率下降、警觉性受损、错误率上升，是飞行安全的重大隐患，已有多起飞行事故的发生与飞行疲劳有密切关系，但疲劳是一种主观感觉，症状不具有特异性和敏感性，缺乏客观评价的手段，如何能够客观、有效、定量地检测和判别飞行疲劳状态对于保障飞行安全具有重大意义。本课题组前期对脑力疲劳检测和瞳孔测量开展了相关研究，探索了疲劳变化的特点和规律，以此为基础本研究拟利用瞳孔运动测量与分析技术，建立瞳孔的测量方法学，通过模拟飞行疲劳负荷，研究人体的疲劳在发生进展过程中，瞳孔变化特征和生物学特性之间的关系，筛选出敏感可靠的瞳孔运动指标，用于检测和判别飞行疲劳及其严重程度。最终为飞行疲劳的客观检测提供理论和方法学依据，保障飞行安全。

Pilots are inclined to get fatigue when face high mental workload in special work environment, which results in lower efficiency, damaged vigilance, and higher error rate. Fatigue was huge threat to air safety, which has been proven to be closely connected with many air accidents. But fatigue is a kind of subjective feeling. The symptoms is not specific and sensitive, which is lack of objective methods to evaluate. It is great meaningful to do the research on how to judge fatigue status efficiently, objectively and quantificationally. Our team did some research on fatigue detecting and pupillometry and found some characteristics and rules of fatigue. Based on these works, this study intends to study the relationship between pupillary changes and biological characteristics by establishing pupillometry, flight fatigue stimulation during the development of fatigue in body experiments. Reliable and sensitive pupillary parameters will be screened out to detect and judge flight fatigue and its extent. This study will provide theory and practical technique for detecting flight fatigue and ensure air safety.