有效地防治放射性脑损伤一直是临床头颈部放射治疗亟待解决的重要问题。本课题组已有研究证实镁离子对放射性脑损伤具有保护作用。近年来研究发现，NF-κB/ICAM-1通路在血管内皮细胞损伤中发挥着重要的调控作用。本课题组前期研究结果表明，镁离子可有效地降低放射引起的脑组织中ICAM-1的表达，并减轻脑血管的损伤。这可能是通过NF-κB/ICAM-1通路发挥的调控作用。为深入探讨镁离子防治放射性脑损伤的分子机制，本课题拟从细胞和动物水平详细研究镁离子通过NF-κB/ ICAM-1通路防治放射性脑损伤的调控机制，研究结果不仅阐明NF-κB/ ICAM-1通路对放射性脑损伤的调控作用，还为镁离子最终在临床放射治疗上应用提供详实的生物学实验依据，对改善放射性脑损伤和提高肿瘤放疗的效果具有重要的指导意义和应用价值。

Effective prevention and treatment of radiation-induced brain injury has always been an important and urgent problem in clinical radiation therapy. Our early work has identified that magnesium can protect the radiation-induced brain injury.Recent studies found the NF-κB/ ICAM-1 pathway had played an important regulating role in injury of vascular endothelial cells.Our early studies have also identified magnesium can effectively reduce the expression of ICAM-1 in brain tissue and the injury of brain vascular through regulating NF-κB/ ICAM-1 pathway.For further study upon the molecular mechanism of magnesium prevention and treatment on radiation-induced brain injury,this work will focus on the regulating mechanism of the NF-κB/ ICAM-1 pathway in the levels of cells and animals.In addition,our results will provide experimental basis for clinical application of magnesium.It will be an important guide to reduce radiation-induced brain injury and improve the control of tumor radiation therapy.