慢性血栓栓塞性肺动脉高压（CTEPH）危害严重且临床隐匿，其形成机制不清楚，早期诊断极为困难。研究显示肺动脉高压形成与血管剪应力变化密切相关，虽然基于流体力学方法用于研究血管剪应力的变化，但在CTEPH中的价值仍有待阐明。近年来双能量CT肺动脉成像虽已成为CTEPH首选的检查技术，但基于双能量CT提供的解剖和灌注信息仍难以满足CTEPH早期诊断。我们前期已建立了急、慢性肺栓塞动物模型，对肺栓塞早期检测方法和流体力学参数的变化进行探索，提出基于流体力学的双能量CT有望提高CTEPH早期检测并用于预后评估的学术思想。本课题拟进一步通过CTEPH动物实验和临床研究，动态连续评估基于流体力学原理的双能量CT综合诊断在CTEPH形成机制、早期诊断和预后分析中的价值，预期能从流体力学角度揭示CTEPH的形成机制，找到CTEPH早期诊断高敏感度的生物力学指标，从而为CTEPH患者的评估提供新的无创手段。

Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious and hidden disease, resulting from its vague pathogenesis, and early diagnosis is very difficult. Although fluid mechanics method was reported to be applied to CTEPH recently and shown that shear stress plays a significant role in the occurrence and progress of pulmonary hypertension, the research value on CTEPH remains to be elucidated. Dual energy CT pulmonary artery imaging has controversially become the first choice for the CTEPH, however, information which dual energy CT provides based on anatomical and perfusion is still difficult to meet the demand of early diagnosis. We have previously established animal models of acute peripheral pulmonary embolism and chronic pulmonary embolism and to explore the early detection and the changes of the fluid mechanics parameters of pulmonary embolism. Accordingly, we brought out the academic thought that dual energy CT based on fluid mechanics could improve early detection of CTEPH and would be useful for prognosis evaluation. This topic proposed by CTEPH animal experiment and clinical research to evaluate dynamically and continuously the value in the pathogenetic mechanism, early diagnosis and prognosis of CTEPH with dual energy CT as well as fluid mechanics comprehensively, expecting to find effective and high sensitive biological indexes for clinical early diagnosis of CTEPH from the point of view of fluid mechanics, and offering a new noninvasive method for the evaluation of patients with CTEPH.