女性盆腔脏器脱垂疾病数字化三维重建研究与空间坐标评估体系的建立

女性盆腔脏器脱垂（FPOP）是非肿瘤性疾病中影响中老年女性生活质量的主要疾病之一，人口老龄化使该病发病率逐年上升。手术是主要的治疗手段，经典修补手术复发率高，现代植入补片强化承托力的方法显著降低复发率，但费用高并发症多，可引发新的症状，故目前仍未找到完美的手术方法，原因之一是评估盆腔缺陷的方法粗糙、间接，导致FPOP的诊断仅反应表观，无法明确内在缺损部位。近年利用MRI进行二维和三维盆腔肛提肌、韧带等研究成为热点，发现MRI对软组织分辨率高的特点在盆底研究中有较大优势。本团队自2009年开始利用MRI进行三维重建技术的学习，掌握了MRI三维重建的常用和关键技术，针对正常人群骨盆、脏器、韧带、盆底肌肉等重建方法进行相关的研究。本课题旨在对FPOP进行全盆腔静态和动态下的三维重建，并建立相应的空间坐标评估体系对盆底脏器及支持结构进行定位量化研究，为FPOP的精确直接全面诊断提供平台。

Female pelvic organ prolapse (FPOP) is one of the main diseases affecting the quality of life of middle aged and elderly women in non-neoplastic diseases. An aging population makes the incidence of this disease to increase year by year. Surgical operation is the main treatment. While the recurrence rate of classic repair surgery is high, the method of patch implantation reinforces the supporting force, which significantly reduce the recurrence rate. However, this method is costly and is associated with complications which may trigger new symptoms. As such, there is still no perfect surgical method. The main reason for this is that the assessment method of pelvic defects is crude and indirect, which results in the diagnosis of FPOP only representing external problems whereas, inner defected parts are not properly assessed. In recent years, research with the use of 2D and 3D MRI reconstructions on the anus levator muscle and ligament has become a hot topic. It found that the characteristic of the high resolution of soft tissue in the magnetic resonance imaging (MRI) has a big advantage in pelvic floor study. Our team commenced the study of 3D reconstruction technology based on the MRI datasets in 2009. We have mastered the most common, key technologies of MRI three-dimensional reconstruction. We have done research targeted on the reconstruction methods of the normal pelvis, viscera, ligaments, pelvic floor muscles. This project is aimed at 3D reconstruction of the whole pelvic base on static and dynamic MRI images from FPOP patients, and establish the corresponding space coordinates assessment system to do location and quantitative research of the pelvic viscera and its support structure, thus providing a FPOP diagnosis platform that is more precise, direct and comprehensive.