脑卒中CT一站式检查可以快速准确无创地获取三维脑灌注血流动力学参数与责任血管血栓信息，是影像学检查的杰出代表。然而，脑卒中CT检查需对脑部进行连续动态容积扫描，辐射剂量较常规CT大幅增加。囿于此，为使脑卒中CT检查更具临床生命力，控制其辐射剂量已成为CT领域亟待解决的关键性课题。本项目拟在保证诊断用影像质量前提下，全力开展基于周期交错投影采样的低剂量脑卒中CT优质成像新方法研究，其重点包括：（1）源于相关知识工程，构建基于周期交错投影采样的脑灌注CT扫描新模式，为（超）低剂量脑卒中CT成像提供全新的数据采集系统模型；（2）结合新扫描模式，构建脑灌注CT增强序列投影数据校正模型与图像迭代重建模型，以期实现准确、鲁棒的（超）低剂量脑灌注CT优质成像；（3）源于新方法重建的脑灌注CT增强序列图像，开展灌注血流参数与血管造影鲁棒估计新模型构建及其影像学分析与评价，以期获得准确的脑卒中CT诊断信息。

One-stop-shop stroke examination quickly and accurately obtaining 3D cerebral blood flow parameters and vascular thrombosis information is an excellent representative of imaging examination. However, stroke CT examination needs to continuously perform repeated volume scans on a region of interest of head, and then the associated x-ray radiation dose is extremely increased over that used in conventional CT examination. Thus, for stroke CT imaging more vitality, controlling the radiation dose is a key topic area to be solved. The project intends to ensure diagnostic image quality under the premise, to carry out research of new methods of high-quality low-dose stroke CT imaging based on period alternating projection sampling scheme, the highlights include: (1) building a novel period alternating projection sampling scheme for cerebral perfusion CT scans, which provides a new CT system model for ultra-low-dose stroke CT imaging; (2) building several cerebral perfusion CT enhanced sequential projections calibration models and image reconstruction models under the new scan scheme, which are expected to realize accurate and robust ultra-low-dose cerebral perfusion CT imaging; (3) building perfusion parameter and angiography estimation models and their analysis and evaluation, in order to obtain an accurate stroke CT diagnostic information.