炎性关节病(IA)是致残率高的一大类疾病，需多种药物联合治疗，治疗靶点为炎性关节增生滑膜，由于药物缺乏靶向性，长期大剂量系统性使用易导致感染、肿瘤等严重副作用，并增加经济负担，探索更安全有效的靶向给药系统成为治疗热点。脂质体有高生物相容性、高载药和亲疏水药物均能负载能力，但并不能实现靶区药物高浓聚；超声能用于靶向定点释药，但普通脂质体没有声敏性；包裹氟碳乳剂的载药声敏乳化脂质体（eLiposomes）则能将超声与脂质体结合起来。基于我们前期研究证实超声联合微泡可定位炎性关节，并可通过空化效应促进药物进入滑膜组织及细胞，同时也已成功制备可载药脂质体，我们拟制备可负载多种药物的靶向声敏eLiposomes，先通过超声造影寻找治疗靶点，然后超声联合微泡介导脂质体释放药物并联合超声空化效应，实现药物在靶区浓聚，探讨治疗机理并评估疗效，旨在为IA探索新型、高效、低副作用的靶向治疗提供理论与实验依据。

Inflammatory arthritis (IA) is a group of rheumatism with high disability and multi-drug treatment is needed in IA, which target is proliferated synovial membranes in inflammatory joints. Due to lack of targeted drugs, severe side effects including infection and tumor caused by long term and high level systematic use of drugs and increase of economic burden, exploring a safer and more effective targeted drug-delivery system has become the focus of treatment. Although liposomes have characteristics of high biocompatibility and drug-loading and the ability to load both hydrophilic and hydrophobic drugs, they cannot realize high drug concentration in the target region; Ultrasound can be used for targeted and site-specific delivery of drugs, but common liposomes are not ultrasound-sensitive. However, the drug-loaded ultrasound-sensitive emulsion liposomes (eLiposomes) encapsulating perfluorocarbon emulsion nanodroplets combines ultrasound and liposomes together. According to our previous studies, we have proved that ultrasound combined with microbubbles could locate inflammatory joints and promote drug’s entry into synoviocytes via cavitation effect, and we also have prepared drug-loaded liposomes. We intend to prepare multi-drug loaded targeted ultrasound-sensitive eLiposomes. We look for the treatment targets through CEUS first, then release drugs from eLiposomes by ultrasound combined with mirobubbles and cavitation effect, and realize the drug accumulation in the target field. We try to investigate the mechanism and assess the efficacy of the treatment. We aim to provide theoretical and experimental evidence for a new, efficient and fewer side effects targeted treatment for IA.