纳米酶的构效关系与催化调控ROS防治传染病的研究

纳米酶（Nanozyme）是一类蕴含酶学催化特性的纳米材料，属于新一代人工模拟酶。申请者首次从酶学角度系统研究了四氧化三铁纳米材料的催化功能，提出了纳米酶新概念，定义了纳米酶活性单位，建立了标准化并研制出世界上首例纳米酶产品。迄今，全球已有26个国家的220多家实验室开展纳米酶研究，形成了纳米酶研究新领域。目前，该领域迫切需要解决的关键问题是如何深入理解纳米酶构效关系，如何通过多学科知识的融合发展完整的纳米酶知识体系，从而实现理性设计和宏量制备，解决当前疾病诊疗中的一些共性问题。为此，申请者利用长期多学科交叉的优势，融合材料、化学、酶学和医学等知识，集中探讨一类纳米酶（如氧化还原酶）的构效关系，结合实验与理论计算设计高活性纳米酶，研究其精确调控ROS的作用机理，解决与ROS相关疾病（如传染病）的一些共性问题，为疾病的防治提供新的思路。

Nanozyme is a type of nanomaterial with enzyme-like activity, belonging to a new generation of artificial analog enzymes. The catalytic function of Fe3O4 nanomaterial was studied from an enzymatic point of view for the first time by the applicant, proposing the new concept of nanozyme, later standardizing this field, producing the world's first nanozyme product. Thus far, more than 220 groups from 26 countries worldwide have carried out nanozyme research, forming a new field of nanozyme research. Presently, the key problems in this field is how to further our understanding of the relationship between nanozyme structure and activity, how to develop a thorough nanozyme knowledge system through uniting multi-disciplinary knowledge, to then implement rational design and macro preparation, and solve common problems in the diagnosis and treatment of current diseases. To this end, the applicant will employ the long-term multi-disciplinary advantages of her research team, combining experience in material science, chemistry and enzymology, to focus on the structure-activity relationship of a class of nanzymes (redox). With experimental and theoretical calculations, we propose to study the mechanism of nanzyme’s precise regulation of ROS, and solve ROS related diseases (such as infectious diseases), and provide new prospectives for the prevention and treatment of diseases.