脑动静脉畸形（AVM）是一种先天性的脑内病变，发生早于运动投射网络的形成，是研究运动投射网络重构的理想模型。目前，AVM患者运动投射网络重构的解剖结构连接及功能连接机制尚不清楚。我们的前期研究结果显示：不同大小、部位的AVM可引起运动投射网络不同的重构模式，且与患者术后运动功能相关；不同部位的皮质脊髓束受损，其术后代偿能力不尽相同。据此，我们初步提出了“运动树”的理论模型，即纤维束受损的时间、空间维度均与其重构的潜力及方式相关。为进一步明确AVM患者运动投射网络重构的拓扑学连接机制，完善“运动树”理论模型。本研究拟通过解剖连接与功能连接的对比分析，探索AVM患者运动投射网络重构的规律；通过先天性疾病（AVM）与后天疾病的对比（低级别胶质瘤、脑卒中），从病变发生时机与重构、纤维受损水平与重构、运动精细程度与重构三个维度验证并丰富“运动树”理论模型；探索新的功能影像学标志，预测患者手术预后。

Cerebral arteriovenous malformations (AVM), as congenital brain lesion, occur before the formation of motor projection networks. Thus, AVM patients are ideal models for the study of motor projection network remodeling. Till now, the topological mechanism of subcortical motor projection network reorganization in AVM patients, including anatomic and functional connectivity, has not yet been elucidated. Our previous studies showed that AVMs with different sizes and locations could cause different models of motor projection system reorganization, and that were significantly associated with the patient's preoperative and postoperative motor function. Furthermore, the compensatory ability is different in patients with different levels of CST involved. Accordingly, we preliminarily proposed the theoretical model of " motor tree " to predict the possible reorganization modes of motor projection system in different situations. To further explore the reorganization mechanism of motor projection network and to improve the theoretical model of "motor tree", this study is scheduled as follows: First, comparing the anatomic connectivity and functional connectivity, to explore the principle of motor projection network reorganization in AVM patients; Second, comparing the reorganization of motor projection in congenital disease (AVM) versus acquired diseases (low-grade gliomas and stroke), to verify and enrich the theoretical model of "motor tree", including the relationship between the timing of lesion occurrence, the involved level of CST, the degree of dexterity of motor function and motor reorganization; Third, to explore new functional imaging signs correlated with good clinical outcomes after radical resection of the lesions to broaden the indications of radical resection in AVM and tumor patients.