蒿属植物富含倍半萜类成分，在植物中，倍半萜还以二聚体的形式存在，倍半萜及其二聚体通常表现出较强的抗肿瘤、抗炎等活性，并且其结构类型丰富，结构呈现明显的多样性，是理想的药物候选化合物；在结构上含有较多的活性基团，结构修饰位点多，是非常理想的药物先导化合物。但是活性倍半萜及其二聚体在植物通常是微量成分，微量成分的分离具有盲目性，且耗费大量时间和财力。本项目选取两种新疆的蒿属植物，采用LC-DAD-MS和抗肿瘤、抗炎和抗白癜风生物活性导向的研究方法，结合现代化的分离纯化技术，从蒿属植物中分离结构新颖的活性倍半萜及其二聚体类的化合物，采用多种波谱和光谱学方法和技术确定化合物结构，为进一步先导化合物的发现奠定物质基础，同时为开发利用银蒿和大籽蒿提供科学依据；也为研发新型抗肿瘤、抗炎、抗白癜风药物以及促进我国创新药物的发展具有重要意义。

Artemisia species are rich with sesquiterpenes. Sesquiterpenes also exist as dimers in plant, and they exhibit significant activities with anti-tumor, anti-inflammation, etc., they also have various structures and are perfect candidate for medicines. Because there are kinds of active groups on the structures, they are easy to structural modification and are suitable for drug lead compounds. But the sesquiterpenes and their dimers are micro constituent in the plants, the isolation of them are sometimes blind and waste lot of time and financial resources. The project choose two Artemisia plants grow in Xinjiang, and guided by LC-DAD-MS and anti-tumor, anti-inflammation and anti-vitiligo activities, also use modern isolation techniques to isolate novel sesquiterpenes and sesquiterpenes dimers and determine the structures by spectral analysis. The results of the project will lay the foundation for further use the compounds as lead compounds, and provide the very important basis to the exploitation and utilization of A. austriaca Jacq. and A. sieversiana Ehrhart ex Willd.. It is also significant meaningful to develop new anti-tumor, anti-inflammatory and anti-vitiligo drugs, meanwhile it can promote the development of innovative drugs of China.