针对可降解镁合金在体内腐蚀降解速度过快及生物相容性差的关键问题，提出新颖的含CaSiO3-Mg2SiO4-CaMgSiO4-CaP生物活性组分陶瓷涂层的一步微弧氧化构建方法，实现降解速度可调控与改善组织治愈双重功能。研究微弧氧化电解液组成设计与工艺参数对涂层组织结构的影响，揭示工艺参数与活性物质定向生成的关系；研究涂层组成、微结构与体外溶血及细胞相容性的关系；通过体外（SBF）实验揭示不同涂层结构对镁合金腐蚀降解与诱导HA沉积过程的影响及机制；以动物模型考察不同涂层材料植入大白兔骨股裸后的降解行为、对骨裸部位的诱导成骨作用及对实验动物的全身影响。对比研究体外与体内腐蚀降解演变规律与差异性，阐明腐蚀降解与诱导生物活性的机理。对涂层进行优化设计，获得诱导骨组织生长及与降解速度相匹配的涂层结构与工艺。本课题对于探索医用镁合金腐蚀调控新方法、丰富腐蚀降解与表面活化理论具有重要的学术与应用价值。

The objective of the research is to propose a novel fabricating method of ceramic coatings with bioactive CaSiO3-Mg2SiO4-CaMgSiO4-CaP phases on magnesium alloy by simple one-step microarc oxidation technique, and further understand the interrelationship between bioactive coating interface and biocompatibility. Such special structural coatings are expected to be an effective way to resolve the two key issues on earlier mechanical failure due to the rapid degradation rate and poor biocomparativity of Mg alloy, by preventing the substrate from rapid release of magnesium ions at the interface and inducing faster bone response. This research will focus on: revealing effects of electrolyte composition design and processing parameters on microarc discharging behaviours, coating growth and microstructure; establishing the relationships between the formation of bioactive constitution and processing parameters, and investigating the effects of coating composition, structure and in vitro hemolysis and cytotoxicity compatibility; examing the effects of different structured coatings on Mg alloy surface on corrosion degradation and HA depositing mechanism through in vitro (SBF) experiments; taking the animal model implanted in the femur shaft of New Zealand white rabbits to understand the in vivo degradation behavior and induing bone response of Mg alloys samples coated with different coatings. Finally, making a comparative research on in-vitro and -vivo corrosion degradation evolution and and finding the difference with the purpose to clarify the mechanism involving corrosion degradation and inducing bioactivity. Based on the results, the process parameters and coating structure were optimized to obtain the matching of new bone induction and degradation rate. The proposed project has a broader societal impact on scientific disciplines and engineering applications. Not only will it enriches the theories of corrosion degradation and surface bioactivation, but will also explore and find the novel way to contol corrosion degradation rate of biomedical magnesiom alloy.