等离激元增强光谱技术在分子光谱领域以其超高的灵敏度引起了研究者的广泛关注。尽管等离激元增强圆二色谱在分子手性识别中有着不可替代的重要性，它与等离激元增强拉曼和荧光光谱相比，仍存在增强效果不理想和增强机理不清晰等问题。鉴于分散型贵金属纳米结构的等离激元光学性质可调性好、不同振荡模式与纳米结构形貌的对应性强的特点，本项目拟以分散型等离激元纳米结构为研究重点，通过调控等离激元的不同振荡模式，筛选出等离激元增强圆二色谱的高效增强体系，并探索其基本增强机制。基于筛选出的高效增强体系，本项目将构建基于增强圆二色谱的新型核酸适配子生物传感器，拓宽圆二色谱在手性药物分析化学中的应用。该申请项目的开展将深化等离激元增强圆二光谱的机理研究，促进发展高灵敏的手性药物传感体系，具有重要的科学价值和现实意义。

Plasmon-enhanced spectroscopic techniques have attracted considerate attention in the field of molecular spectroscopy due to their high sensitivity. Although plasmon-enhanced circular dichroism spectroscopy may play an irreplaceable role in molecular chirality sensing, compared with plasmon-enhanced Raman and fluorescence spectroscopy, a rigorous mechanism for plasmon-enhanced circular dichroism spectroscopy is still lacking. Moreover, it still suffers with low enhancement factors. In this study, discrete plasmonic nanostructures were employed as substrates for plasmon-enhanced circular dichroism spectroscopy, due to their highly tunable plasmonic properties. The interplay between different plasmon resonance modes of discrete plasmonic nanostructures and the enhancement factors will be investigated, and the underlying enhancement mechanisms will be elucidated. Based on the screened high-enhancement system, aptamer-based biosensors will be developed and thus extend the application of circular dichroism spectroscopy in analytical chemistry of chiral drugs. This study will provide mechanistic insights in plasmon-enhanced circular dichroism spectroscopy and lay the groundwork for developing new biosensors for chiral drugs; therefore, it is of vital importance in both fundamental and practical research.