针对传统对映体传感技术的局限性，提出基于外在超手性Plasmonic纳米结构（ESCPS）的生物分子构象传感技术，利用超手性场对手性物质与电磁场之间非对称相互作用的增强作用和外手性效应在对映体传感方面的高效性，实现高灵敏、实时和高通量的构象检测。本项目将以构象传感为出发点，深入研究外手性效应和超手性场的形成机理；厘清外手性效应、超手性场与ESCPS的拓扑形貌、环境折射率、SPP类别（局域SPP、传播SPP等）等影响因素之间的内在规律，建立基于ESCPS的生物分子构象传感模型，进而发展生物分子构象传感的理想超手性场和传感基底的设计方法。结合实验室在手性超材料及其与生物分子相互作用方面的特色积累，开展生物分子取向和构象变异调控、以及生物分子构象传感实验，验证理论和方法的正确性。本课题研究，还将推动外手性效应和超手性场的理论发展，及其在非对称化学合成、Raman散射光活性等领域的应用。

In this project, we propose a biomolecular conformation sensing technology based on the extrinsic super-chiral plasmonic nanostructures (ESCPSs) to overcome the limitation of the traditional enantiomers, where the super-chiral field excited near ESCPSs can enhance the asymmetric interactions between chiral substrates and the circular parilation light, and the extrinsic chiroptical effect from ESCPSs can improve the detection efficiency. This technology is suitable for the the ultrasensitive, real time and high-throughput detection, and can meet the requirement of the current scientific and technological development, especially for the genomics, proteomics, drug screening and so on. We will start with some ESCPSs with representative topological morphology, focus on the conformation sensing requirement, and research the formation mechanism of the extrinsic chiroptical effect and super-chiral field by the relatively theoretical and experimental method.Through clarifying the relationship between the super-chiral field, extrinsic chiroptical effect and the structure dependent properties, such as the topological morphology of ESCPSs, the surrounding refractive index and surface plasmonic polariton, we will set up a biomolecule conformation sensing model based on ESCPSs, and develop the designing method of the idea super-chiral field and the conformation sensing substrate.Based the characteristic research accumulation on the research of chiral metamaterials and the interaction between chiral plasmonic nanostructures and chiral molecules, we will carry out the experimental research on controlling the conformational variants and the orientation of biomolecules and the enantiomer sensor, and verify the developed theory and the method that used in experiment.The research of this project will also promote the theoretical development and applications of super-chiral field and ESCPSs in other fields, such as asymmetric synthesis and Raman optical activity.