声动力治疗在口腔鳞状细胞癌(OSCC)无创治疗中极具有应用价值。但5-ALA在体稳定性差和肿瘤组织靶向能力不足，限制了其抗肿瘤效果及临床转化应用。本项目拟利用可降解黑磷纳米片作为输送载体，修饰T7小分子多肽构建靶向OSCC的纳米声敏剂递送系统，实现5-ALA高效靶向给药，提高声动力治疗OSCC的效果，并阐明基于纳米声敏剂的声动力治疗通过激活铁自噬释放Fe2+调控细胞内铁稳态，促进OSCC发生铁死亡的分子机理。建立一种精准高效靶向OSCC的声敏剂纳米递送体系，为探索高效声动力治疗OSCC方案提供理论依据和新思路。

Sonodynamic therapy was valuable in noninvasive treatment of oral squamous cell carcinoma (OSCC). However, the unstable of 5-ALA in vivo and the insufficient targeting ability of tumor tissues limit its anti-tumor effect and clinical translational application. This project intends to use biodegradable black phosphate as nano-transmission carrier and modifying T7 small molecule polypeptide to build nano-sonosensitizer delivery system targeted OSCC, to achieve 5-ALA efficient targeted drug delivery and improve the antitumor effect in the treatment of OSCC. Clarifying the molecular mechanism of that based on nano- sonosensitizer sonodynamic therapy can release Fe2 +by activating ferritinophagy to regulation cell iron homeostasis to promote ferropotosis of OSCC. A nano-delivery system of sonosensitizer targeting OSCC with high accuracy and efficiency was established to provide theoretical basis and new ideas for the exploration of high-efficiency sonodynamic treatment of OSCC.