癫痫猝死（SUDEP）因其严重的危害性而日益受到关注，但至今原因不明。SUDEP致死的直接原因是心脏骤停和呼吸停止，我们发现岛叶可以影响呼吸及心血管功能。有报道颞、额叶癫痫发作时均向岛叶发送信息。因此推测岛叶可能是SUDEP的关键部位。为证明此论点，采用立体定位技术建立颞、岛叶癫痫动物模型并分别点燃，通过SUDEP发生率及神经元细胞外放电记录证明岛叶是癫痫大鼠SUDEP的关键部位。其次证明岛叶癫痫导致的呼吸、循环功能障碍及SUDEP是由缰核及下丘脑介导，最后通过植物神经系统实现。第三，通过免疫组化等技术检测癫痫发作时脑内神经递质的变化，为探索预防和治疗SUDEP有效手段奠定理论基础。

The sudden unexpected death in epilepsy (SUDEP) has attracted considerable attention due to its serious health hazard, but the mechanisms underlying SUDEP are not still understood as yet. The direct cause of SUDEP is ictal asystole and apnea. We found that insular cortex controls the respiratory and cardiovascular functions through the regulation of the sympathetic and parasympathetic systems. And some reported the temporal ,frontal epilepsy kindled send out signals to insular cortex respectively. Therfore,we presumably the insula may be the key site of SUDEP happened. For this purpose, establishing the animal models of epilepsy on temporal lobe, and the insular cortex respectively rely on the stereotactic technique, and kindling these animals respectively. In this process,basing on the statistics of the rate of death and the extracelluar discharge recording of neurons to demonstrate that the insula is a key component of SUDEP. Secondly, we will prove that the control of respiratory and circulatory dysfunctions induced by SUDEP pullulated from insular cortex epilepsy, are by means of habenula and hypothalamus and finally mediated by autonomic nervous system. Thirdly, through immunohistochemistry techniques to detect changes of brain neurotransmitter to set up a theoretical foundation to explore effective means of prevention and treatment of SUDEP.