眼眶位置和结构特殊，骨壁一侧为副鼻窦空腔，局部血供差、骨再生能力低，外伤缺损后修复困难，常导致严重视功能障碍、感染和颅面部畸形，需植入不可降解材料修复骨缺损，但存在移位、排斥、感染等严重并发症。我们前期研究证明组织工程技术可用于眼眶骨再生，但眼眶壁薄，缺损后眼眶通过副鼻窦和外界相通，支架材料植入后不仅降解速率不匹配新骨形成，移植细胞成活率低，而且感染率高。近来，研究证明人源抗菌肽LL37除具有抗微生物活性、免疫调节功能，还参与伤口的愈合和血管的发生，能促进细胞增殖，从而促进组织再生。因此，本项目通过构建携带LL37多肽的功能化聚合物支架PFM用于眼眶骨修复和再生，探讨其修复眶壁标准骨缺损的有效性和安全性，并从细胞、分子和动物水平，阐明其促进骨修复的机制，以期为临床眼眶骨再生修复提供理论基础和新思路。

The special structure and location of orbit, the adjacent paranasal sinuses,the poor blood supply and bone regeneration ability make the orbital wall defect repair difficult, leading to severe visual loss,infection and middle face malformation and other functional disorders which needs to implant unbiodegradable materials. However, the implanted materials may cause malpositon,rejection and infection complications.Our previous studies showed that tissue engineering can be used in orbital bone regeneration. However，because of the communation of orbit and enviroment through the paranasal sinuses, after implantation of biomaterials the mismatching degradation of the biomaterials and low viability of implanted stem cells even the high exitence of infection make it difficult to regenerat orbital bone. Recent studies proved that the antimicrobial peptide LL37 possess potent and broad spectrum antimicrobial activity. LL37 also exhibits multiple bio-functions in wound healing and agiogenesis，even promotes cell proliferation and tissue regeneration. This project begins with our desire to generate a functional polymeric scaffold carring LL37 peptide to repair orbital bone defecct and promote orbital bone regeneration, and evaluate the feasibility and safety of applying the composit in orbital bone regeneration. Moreover, through analyses of cell markers and comprehensive tests, this project intend to clarifies the mechanisms LL37 involved in the repair of bone defects, thereby providing an experimental basis for the clinical treatment of orbital bone defects.