ZD制剂对竞技运动赛马肢体非开放性软组织损伤（动物模型）作用机制的研究

随着经济的发展，我国竞技运动赛马正迅速兴起，而赛马在运动中常发疾病是肢蹄的软组织损伤。据统计，该病占外科疾病的70%以上。国外目前对赛马肢蹄软组织损伤治疗主要采用非甾体类药物（NSALDS），临床研究表明：长期应用该类药物会产生褚多不良反应且难以去除病因，使赛马被迫淘汰。祖国中蒙医学在急性软组织损伤治疗中积累了丰富的经验，中蒙药是治疗该病的特色之一，但目前对赛马的作用机制研究甚少，国内外赛马未见有应报道。 本课题是筛选多种中蒙药制成ZD制剂，应用该制剂对赛马肢蹄非开放性软组织损伤的动物模型进行药效学研究。从组织形态学、血液动力学、血管通透性、炎症介质、细胞调亡、抗炎分子等方面验证其疗效，探讨其机制并应用于赛马临床。为尽快研制出治疗赛马肢蹄非开放性软组织损伤的中蒙药制剂提供理论和实践依据。

The modern athletics horses is rising rapidly with the development of the our country's economy. The non-open soft tissue injury in hoof and limb of athletics horses is the most common disease when racing horses are in the movement. According to statistics that it's morbidity is 70 persent in all surgical diseases. Nonsteroidal anti-inflammatory drugs therapy is the main method of treating soft tissue injury in athtetics on abroad .The clinical study shows that the long-term administration of NSALDs can induce many kinds of adverse reactions. It's also hard to eradicate the pathogenesis so that the result shows that horses was forced to eliminated. The traditional Chinese veterinary medicine accumulates many experiences about the treating acute soft tissue injury. One of the characteristics is the external application. However its mechanism is less known and reported in the aspects of foreign atheltes horses. This subject utilizes medicinal extract for exterior application of the ZD preparation to study the medical pharmacodynamics in non-open soft tissue injury of animal model. the effect of the square of medicine is confirmed from the aspects of organization morphology hemodynamic blood vessels permeability inflammation cell apoptosis anti-inflammatory molecules. The mechanism was discussed and apply to athletes horse clinical, To provide theoretical and practical basis that chinese herba preparation treat no-open injury hoof and limb of athletics horses is developed as soon as possible.