将细胞定位装配到芯片的设计位置形成有功能的组织模型，是细胞芯片向组织模型化、人工组织器官向功能和信息化方向发展面临的关键科学问题，而细胞三维打印和细胞芯片技术的结合为解决这一问题提供了新的理论和技术。 本项目研究用细胞三维打印将细胞精确装配到芯片设计位置、形成功能组织模型并原位检测其生理信号的理论和方法。课题以与高发疾病相关的能量代谢系统功能组织为切入点，在建模分析各组织的细胞种类、组织结构和功能后；设计和制造面向细胞三维打印和组织功能需求的集成型细胞芯片；研究用细胞三维打印技术在芯片上精确装配细胞所涉及的材料成型机制和精度控制方法；在芯片上完成多种细胞组装，诱导细胞形成功能组织单元并形成反馈调控系统，实现多生理信号的原位同步检测。完成建立具有能量代谢系统组织模型的细胞芯片，并初步探讨相关技术在高内涵药物筛选领域中的应用。研究将为组织工程、人工器官、细胞芯片和药物筛选提供新的理论和技术。

In engineering tissue model and living system on chip, cell chip techniques were confronted with the obstacle that how to put different cells into designated places to match the designed pattern of the chip. 3D Cell printer technique provides new theories and techniques to resolve this problem. In this proposal, we study the theories and techniques that assemble cells on designated places to match the designed pattern of chip. Through studing the metabolic system, we get cell types and organization structures for establishing living system on chip. We study the materials and precision control that involved in precise assembling cells on chip. We design and fabricate integrated cell chip for cell assembly technique and living system. Then, we induce the cells on chip to be a living system and detect cells in situ and synchronous. Lastly, we study the application of this living system on chip in drug discovery. Construction and study of such cell chip systems will develop new technologies for tissue engineering, cell chip and drug discovery.