在我国，冠心病发病率及死亡率逐年上升，降低了冠心病患者生活质量并加重社会经济负担。前期研究表明:大部分冠心病患者存在菌群失调，以痰瘀互结证居多。国外研究显示ACVD患者肠道微生物健康状态的偏离会影响心血管的健康。TMA/FMO3/TMAO通路是调节炎症和脂质代谢的主要通路，肠道菌群可经过此通路将食物中的胆碱最终转化为TMAO，而TMAO集中作用于促进血小板聚集、影响胆固醇代谢、促进血管炎症反应，造成动脉粥样硬化而致冠心病。丹蒌片是临床常用治疗冠心病痰瘀互结证的中成药，疗效显著，现代药理研究已证实丹蒌片能调节高脂血症大鼠的脂代谢，明显缩小冠心病痰瘀互结证大鼠心肌梗死面积，减轻心肌组织和心肌细胞病理损伤。本研究选取SD大鼠作为实验对象，建立冠心病痰瘀互结证合并肠道菌群失调模型，给予不同剂量丹蒌片悬混液灌胃治疗，测量相关实验指标，研究丹蒌片是否能通过TMA/FMO3/TMAO通路影响肠道菌群。

In our country, the incidence of coronary heart disease, hospitalization rate and mortality are on the rising，causing a serious impact on the quality life of patients with coronary heart disease and social economy.Our previous study showed that a number of patients with coronary heart disease have intestinal flora inbalanced, in which patients with phlegm-stasis syndrome take the majority part. Foreign studies have shown that the deviation of the intestinal microbial health status of patients with ACVD will affect cardiovascular health. The TMA/FMO3/TMAO pathway is the main pathway regulating inflammation and lipid metabolism. The gut flora can ultimately convert choline of food into TMAO through this pathway.TMAO plays a central role in promoting platelet aggregation, affecting cholesterol metabolism and promoting vascular inflammation, resulting in atherosclerosis and coronary heart disease. As a commonly clinical Chinese medicine used in the treatment of phlegm-stasis syndrome of coronary heart disease, the effect of Dan-lou tables is significant,modern pharmacological studies have confirmed Dan-lou tables can regulate lipid metabolism of hyperlipidemic rats, significantly reduce myocardial infarction area of rats of phlegm-stasis syndrome of coronary heart disease and reduce myocardial tissue and myocardial cell pathological damage.In our study, SD rats were selected as experimental subjects, through the establishment of phlegm-stasis syndrome of coronary heart disease combined with intestinal flora imbalance model, giving different doses of Dan-lou tables suspension mixture gavage treatment and measuring relevant experimental indicators to explore whether intestinal flora can be affected by Dou-lou tables through TMA/FMO3/TMAO pathway.