卡波西肉瘤(Kaposi's Sarcoma，KS)是最为常见的艾滋病相关的恶性肿瘤，也是艾滋病相关恶性肿瘤中的最主要死因。在中国，已报道的艾滋病相关KS和经典KS病例主要集中在新疆，且多见于维吾尔族，申请者的研究也符合这一特点。目前国内外研究认为KSHV感染是KS病因之一，但KSHV导致宿主细胞恶性化的机制尚不清楚，国外已有的研究认为KSHV表达vFLIP蛋白可能在KS发病中起重要作用，vFLIP蛋白是与细胞FLIP同源的蛋白，而FLIP蛋白是一种与细胞凋亡密切相关的蛋白。本研究以维吾尔族HIV相关KS及经典KS患者为主要研究对象，利用体内、体外实验，结合分子生物学、免疫学技术探讨vFLIP在KS组织及正常组织中的表达及其对FAS/FasL凋亡途径的影响，验证vFLIP在体内和体外对细胞凋亡、增殖的影响，为研发针对干扰病毒vFLIP蛋白表达的药物治疗艾滋病相关KS提供理论基础。

Kaposi's Sarcoma(KS) is the most common neoplasms, as well the major cause of death in AIDS patients. Xinjiang had the leading HIV-infected ratio in China ,and the classic KS incidence of Uighur is much higher than those of any other ethnics in China. The applicant of this research suits this superiority. A great many of researches nation and abroad revealed that infection of KSHV was the main mechanism of KS, but it remained unclear how KSHV induced the tissue malignancy, some studies abroad showed that expression of vFLIP by KSHV maybe lead this happened. vFLIP is homologous to cell FLIP expressed by virus , FLIP is regarded high related to cell apoptosis. This research is designed to study the expression of vFLIP in HIV-KS and classic KS in Xinjiang U patients, the effect of vFLIP on apoptosis bypass FAS/FasL passway,and provid a novel means for state evaluate for KS, a theoretical based for pharmaceutical development for KS therapy .