高冲击运动中人体下肢所承受的巨大关节负荷，被认为是造成膝关节损伤和慢性退行性骨关节病的重要原因。但到目前为止，准确认识和理解高冲击运动过程中在体膝关节的三维运动和载荷仍存在理论和技术上的瓶颈。本研究拟采用国际领先的高速双平面正交高速荧光成像技术和运动捕捉系统，结合医学影像二维/三维关节自动配准技术、个体6自由度运动驱动膝关节动态有限元建模等方法，系统研究：① 正常人高速、高冲击性动作过程中在体膝关节结构连续且完整的运动学和动力学特征；② 建立个体化6自由度膝关节有限元模型，获取在体膝关节运动过程中内部骨骼、软骨等结构的生物力学载荷特征；③ 结合逆向动力学等宏观生物力学分析，建立运动和负荷特征在内/外部和时/空上的耦合关系；④ 引起膝关节损伤和关节疾病的运动学以及动力学潜在危险因素和可能的生物力学新机制，为进一步改进运动训练方法、完善膝关节损伤的预防、治疗和康复奠定理论和方法学基础。

The lower extremity of the human body often bear a great articular load due to high impact activities, which has been widely accepted as a major risk factor for knee injuries and osteoarthritis. However, comprehensive understanding of the in vivo knee kinematics and loads has met a bottleneck so far both in theory and technology. A novel synchronized high-speed biplane fluoroscopic imaging system and motion capture system, accompanied with an automatic 2D–3D fluoroscopic image-model registration technique as well as an explicit dynamic 6DOF finite element model of the knee, will be used to 1) measure the 3D in vivo knee kinematics and kinetics of healthy participants during high-speed and high-impact activities; 2) establish an individualized 6DOF finite element model of the knee in order to further simulate the biomechanical contact features the loading rate of the articular cartilage and meniscus; 3) build relationships between movement and loading both on the external / internal and temporal / spatial aspects; 4) explore the potential risk factors and possible biomechanical mechanism of knee joint injuries and diseases with knee kinematics, kinetics and dynamics characteristics. These results will provide valuable information for the improvement of sports training, the pathology treatment, and the rehabilitation program of the knee joint injury.