高原脑水肿（HACE）是急性高原病（AMS）的继发脑部综合症，具有明显的易感倾向，但目前临床上缺乏对这类疾病高危人群的筛选方法，现有的诊断方法也存在着工作量大、重复性差、准确性因人而异的缺点，难以实现病情的连续监测。最新的病理生理先导理论认为HACE是一种血管性水肿，与大脑毛细血管结构改变导致血脑屏障受损有关。大脑毛细血管床动力学性能反映了大脑微动脉阻力血管，特别是管壁平滑肌的结构和功能，与HACE发生、发展和转归的关系更密切。本项目拟研究非平稳动态脑血流自动调节功能、毛细血管弹性及血管阻力等大脑毛细血管床动力学性能的检测评价方法，以进入4000米高海拔地区的平原旅游者为研究对象，通过对HACE患者和健康人群的对比分析，探索HACE患者大脑毛细血管床动力学性能突变的特征，筛选出高敏感性的特征参数；研究特征分类，建立完善无损便携诊断监测系统。为HACE易感筛选、临床诊断和治疗提供依据和手段。

High altitude cerebral edema (HACE) is the secondary syndrome of the acute mountain sickness (AMS). However, due to the obvious susceptibility, the method for discriminating HACE is lacked. The HACE diagnosis method currently used in clinic is also limited by low efficiency, insufficient repeatability and objectivity. According to the latest leading pathology and physiology theories, the HACE is a kind of vascular edema resulted from the change of the cerebral capillary vessel structure and function, which cause the blood-brain barrier impairment, and could impact on the HACE occurrence, development and recovery. In present project, the detection and evaluation methods for dynamic performances of cerebral capillary bed, including the non-stationary dynamic-cerebral-autoregulation, cerebral capillary elasticity and resistance will be studied. Considering the travelers entering into the area with 4000m altitude as the research objects, and by comparing the detected dynamic performances of cerebral capillary beds between HACE groups and healthy groups, the abrupt change characteristics will be explored, and then the sensitive characteristic parameters will be discriminated. Finally, the approach for the auto-classifying the selected characteristic parameters will be studied and non-invasive portable diagnosis and monitoring system will be developed. The project aims at providing evidences and methods for HACE discrimination, diagnosis, prevention and therapy.