同源重组作为生物进化的动力之一，在哺乳动物有性生殖过程中保障同源染色体准确配对和分离而形成配子。在多个物种里，重组频率在个体和群体之间都有差异，研究表明重组次数或频率影响繁殖力。同源重组并不是随机出现在染色体上，而是较为集中的出现在被称为“重组热点”的狭窄的染色体区间。在人和鼠中，PRDM9基因决定了重组热点分布位置，该基因被认为是物种进化和生殖隔离的主要基因。本研究拟利用现有的中西方猪种的高通量重测序数据发掘高密度的遗传变异，再以遗传标记间的连锁不平衡来推断历史重组事件和重组热点。我们以期构建出猪基因组上的精细重组热点图谱，理解PRDM9基因对猪重组热点分布的指导作用。此研究将能使我们更加深刻的理解哺乳动物的遗传控制机制，认识影响繁殖力的遗传基础。

Homologous recombination is one of the evolutional forces. In mammalian sexual reproduction, recombination establishes physical connection between homologous chromosomes and directs their precise segregation in meiosis I. Inter-individual variation in recombination rates has been documented for quite some time in several organisms, which have has been linked with fertility traits. Recombination events are not evenly distributed along genome, usually concentrate in narrow regions and constitute into numerous “hotspots”. PRDM9 is major specifier for locating of recombination hotspots in human and mice, and is thought to be the main driver in speciation and evolution. Taking advantage of existing high-throughput re-sequencing data of Chinese and western pig breeds, we will infer genome-wide historical recombination events and hotspots using linkage disequilibrium information of populations. Our goal is to have a fine-scale map of recombination hotspots for pigs, and understand how PRDM9 directs locating of hotspots. Study of this kind would enable us understand further on genetic components affected recombination in mammals, would also contribute to fertility related research.