塑料制品不断进入水环境，形成微塑料（MPs），并与药物活性化合物（PhACs）等新型污染物构成复合污染，对水生生态系统造成潜在威胁。海洋环境中MPs的复合污染和生态风险已成为近年来的研究热点，然而在淡水环境中相关研究仍十分匮乏。本研究基于北太湖MPs与PhACs的复合污染现状，结合现场监测和室内模拟实验，首先研究环境相关浓度下典型MPs和PhACs在不同营养级淡水生物的组织分布和生物累积，解析PhACs的代谢途径，揭示MPs对PhACs生物代谢转化的影响规律；然后通过对比单一/联合暴露下淡水生物生长、代谢、氧化应激和神经功能在细胞和基因水平上的差异性响应，揭示水体中共存的MPs和PhACs的交互作用机制；最后分析环境因素对复合污染交互作用的影响，识别主要影响因素。结果可为新型污染物风险管理提供科学依据，对维护实际复合污染水体的生态安全具有重要意义。

Plastic products are continuously discarded into the aquatic environment and eventually degrade to microplastics (MPs). MPs would coexist with other emerging contaminants, such as pharmaceutically active compounds (PhACs), to form combined pollution, resulting in a potential health threat to aquatic ecosystem. In recent years, the importance of combined pollution with MPs in marine environments has been emphasized. However, in freshwater environments, the relevant information remains limited. Based on the current status of the MPs-PhACs combined pollution in Northern Taihu Lake, this project will be conducted through in-situ monitoring and experiments in simulant condition. Firstly, the tissues distribution and bioaccumulation of MPs and PhACs will be evaluated at environmentally relevant concentrations in the freshwater organisms occupying different trophic levels; the metabolism pathways of PhACs will also be characterized to reveal the effects of MPs on PhACs metabolisms. Then, the differences between single and combined effects of MPs and PhACs in growth, metabolism, antioxidation and nerve function will be analyzed at cell and gene levels, to understand the interactive mechanism between MPs and PhACs. Finally, the effects of environmental factors on the interaction between MPs and PhACs will be evaluated to identify the mainly influencing factors on the combined pollution of MPs and PhACs. The results of project can be used for the risk management of emerging contaminants in freshwater environments and will be significant in the ecological security of combined polluted waters.