心脑血管疾病防治的新靶点：α7受体的研究

ABR功能缺陷导致心脑血管疾病预后不良的分子机制是α7烟碱型乙酰胆碱受体(简称α7受体)的功能减弱。研究表明激活α7受体后有四大功能：抗炎、抗细胞凋亡、抗氧化应激、促进血管新生。本项目主要研究激活α7受体对心脑血管疾病的防治作用，确定α7受体作为心脑血管疾病防治的新靶点；研究激活α7受体后发挥抗炎、抗细胞凋亡、抗氧化应激和促进血管新生作用的下游分子生物学机制；筛选α7受体激动剂，并探讨这些激动剂作为候选药的可能性。

ABR dysfunction leads to a poor prognosis in cardiovascular and cerebrovascular diseases. The possible mechanisms may be the weakening of the function of α7 nicotinic acetylcholine receptor (α7nAChR). The effect of activation of the α7 receptor could be summarized as: (i) inhibiting inflammation; (ii) inhibiting apoptosis; (ii) inhibiting oxidative stress; and (iv) promoting angiogenesis. This program was designed to study the protective effects of the activation of α7nAChR on cardiovascular and cerebrovascular diseases; to determine the α7nAChR as a new target for cardiovascular and cerebrovascular diseases; to investigate the downstream signal mechanism of activation of α7nAChR; to screeningα7nAChR agonist and to explore the possibility of these agonists as candidate drugs.