脑卒中是一种常见的疾病，绝大多数脑卒中病例是由短暂性或永久性脑血管闭塞引起的缺血性脑血管病，小胶质细胞为特化的巨噬细胞，在中枢神经系统中进行吞噬作用，清除病原体或受损的神经元。小胶质细胞激活对于减轻神经细胞凋亡，增强神经发生至关重要，并能促进脑缺血后的功能恢复。基于促炎或抗炎细胞因子的刺激，小胶质细胞通常可以极化为促炎表型和抗炎表型，促进M2表型极化有助于促进损伤后的组织再生，而特异性的抑制小胶质细胞的TLR2和TLR4受体，从而促进小胶质细胞向M2表型极化，可能是有效治疗缺血性卒中的有效策略之一。塞络通胶囊（SLT）是本团队选用人参、银杏叶、西红花研发的治疗血管性痴呆的中药复方制剂，本课题以期从小胶质细胞的功能阐释SLT可能是通过抑制小胶质细胞的TLR2和TLR4受体，从而促进小胶质细胞向M2表型极化，进而达到抗炎目的，发挥其对缺血后神经损伤的保护作用。

Stroke is a common disease. The vast majority of stroke cases are ischemic cerebrovascular diseases caused by transient or permanent cerebrovascular occlusion. Microglia are specialized macrophages in the central nervous system. Phagocytosis is performed to remove pathogens or damaged neurons. There is increasing evidence that microglia activation is essential for attenuating neuronal apoptosis, enhancing neurogenesis, and promoting functional recovery after cerebral ischemia. Based on the stimulation of pro-inflammatory or anti-inflammatory cytokines, microglia can usually be polarized into pro-inflammatory phenotypes and anti-inflammatory phenotypes, promoting M2 phenotypic polarization helps promote tissue regeneration after injury, while specific Inhibition of TLR2 and TLR4 receptors in microglia, thereby promoting the polarization of microglia to M2 phenotype, may be one of the effective strategies for the effective treatment of ischemic stroke. Slotong Capsule (SLT) is a traditional Chinese medicine compound preparation for the treatment of vascular dementia developed by ginseng, ginkgo biloba and saffron. The purpose of this study is to explain the function of microglia by inhibiting microglia. The TLR2 and TLR4 receptors promote the polarization of microglia to the M2 phenotype, thereby achieving anti-inflammatory effects and exerting its protective effect on post-ischemic nerve damage.