腹主动脉瘤腔内修复术（endovascular aneurysm repair，EVAR）已成为治疗腹主动脉瘤（AAA）的一种安全有效方式。II型内漏是EVAR术后特有并发症之一，通常认为持续内漏可能引起瘤腔增大而导致动脉瘤破裂而需要治疗。然而目前II型内漏引起瘤腔变化以及治疗的存在争议，致使本研究希望从血流动力学角度探讨II型内漏的对腹主动脉瘤壁和支架本质性影响的临床过程。本研究借助II型内漏计算机三维模型和3D打印硅胶体外模型，通过流固耦合方式和体外灌注系统方式分析不同II型内漏的血流动力学对瘤壁及支架应力分布，揭示II型内漏对瘤壁及支架的力学影响。进一步，通过犬II型内漏模型，比较6月后瘤壁应力-应变关系、瘤壁应力负荷以及弹力纤维和胶原蛋白改变，探索II型内漏对瘤壁应力负荷-结构关系。最终，揭示EVAR术后II型内漏引起的本质病理过程，为临床II型内漏是否干预提供理论依据。

Endovascular aneurysm repair (EVAR) is introduced as a safe treatment option for patients with abdominal aortic aneurysm(AAA). There is a general consensus that reinterventions are necessary to prevent adverse events, including aneurysm sac enlarge or rupture, in patients with type II endoleaks. Howerver, the nature clinical course of type II endoleak is unclear because of reported heterogeneity in aneurysm sac changes and the need for reinterventions. Employing a fluid–structure interaction solver and a perfusion system, aneurysm wall and.stent stress force were computed for the 3D computer and 3D printing model of types II endoleaks. Furthermore, these changes of hemodynamic, stress-strain and tissue structural will be analysed in the beagle dog AAA model of type II endoleaks within six months.The project will also indicate the correlation between hemodynamic status and aoritc histopathology. Finally,the study will indicate that.type II endoleak induce the intrinsical influence of aneurysm wall and stent. This results will be benefical to guide the therapy of type II endoleak following EVAR.